Journal
CELL AND TISSUE RESEARCH
Volume 384, Issue 2, Pages 313-324Publisher
SPRINGER
DOI: 10.1007/s00441-020-03355-x
Keywords
Niacin; Mammary gland development; Akt; mTOR; ERK1; 2; Pubertal mice
Categories
Funding
- National Natural Science Foundation of China [31873004, 31672509]
- Jilin Scientific and Technological Development Program [20190103021JH]
- JLU Science and Technology Innovative Research Team
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This study aimed to investigate the effects of niacin on mammary gland development in pubertal mice, and found that niacin stimulates mammary gland development through the Akt/mTOR and ERK1/2 signaling pathways by promoting the synthesis of cell proliferation markers.
Previous studies have shown the effects of vitamins on the development of the mammary gland. However, the role of niacin in this process has not been reported. Therefore, the aim of this study is to investigate the effects of niacin on mammary gland development in pubertal mice and to use a mouse mammary epithelial cell line to study the underlying mechanism. The results showed that niacin could activate the AKT/mTOR and ERK signaling pathways and increase phosphorylation of 4EBP1 to promote the synthesis of cell proliferation markers, leading to the dissociation of the Rb-E2F1 complex in mMECs. In addition, 0.5% niacin promoted mammary duct development, increased the expression of cyclin D1/D3 and PCNA and activated Akt/mTOR and ERK1/2 in the mammary glands of pubertal mice. These results strongly suggest that niacin stimulates mammary gland development in pubertal mice through the Akt/mTOR and ERK1/2 signaling pathways.
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