Journal
CELL
Volume 184, Issue 9, Pages 2362-+Publisher
CELL PRESS
DOI: 10.1016/j.cell.2021.02.042
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Funding
- National Natural Science Foundation of China [82073621]
- Bill and Melinda Gates Foundation [INV-006379]
- National Science and Technology Major Projects of Drug Discovery [2018ZX09101001]
- National Science and Technology Major Projects of Infectious Disease [2017ZX10304402]
- Bill and Melinda Gates Foundation [INV-006379] Funding Source: Bill and Melinda Gates Foundation
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The 501Y.V2 variants of SARS-CoV-2 with multiple mutations are rapidly spreading from South Africa to other countries, showing reduced susceptibility to neutralizing antibodies and potential compromise of monoclonal antibodies and vaccines. Enhanced infectivity in murine ACE2-overexpressing cells suggests the possibility of transmission to mice.
The 501Y.V2 variants of SARS-CoV-2 containing multiple mutations in spike are now dominant in South Africa and are rapidly spreading to other countries. Here, experiments with 18 pseudotyped viruses showed that the 501Y.V2 variants do not confer increased infectivity in multiple cell types except for murine ACE2-overexpressing cells, where a substantial increase in infectivity was observed. Notably, the susceptibility of the 501Y.V2 variants to 12 of 17 neutralizing monoclonal antibodies was substantially diminished, and the neutralization ability of the sera from convalescent patients and immunized mice was also reduced for these variants. The neutralization resistance was mainly caused by E484K and N501Y mutations in the receptorbinding domain of spike. The enhanced infectivity in murine ACE2-overexpressing cells suggests the possibility of spillover of the 501Y.V2 variants to mice. Moreover, the neutralization resistance we detected for the 501Y.V2 variants suggests the potential for compromised efficacy of monoclonal antibodies and vaccines.
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