Related references
Note: Only part of the references are listed.Optimization of AsCas12a for combinatorial genetic screens in human cells
Peter C. DeWeirdt et al.
NATURE BIOTECHNOLOGY (2021)
A CRISPR-based base-editing screen for the functional assessment of BRCA1 variants
Jiyeon Kweon et al.
ONCOGENE (2020)
LDLR-mediated lipidome-transcriptome reprogramming in cisplatin insensitivity
Wei-Chun Chang et al.
ENDOCRINE-RELATED CANCER (2020)
Continuous evolution of SpCas9 variants compatible with non-G PAMs
Shannon M. Miller et al.
NATURE BIOTECHNOLOGY (2020)
Efficient, continuous mutagenesis in human cells using a pseudo-random DNA editor
Haiqi Chen et al.
NATURE BIOTECHNOLOGY (2020)
Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants
Russell T. Walton et al.
SCIENCE (2020)
Structural basis for allosteric PARP-1 retention on DNA breaks
Levani Zandarashvili et al.
SCIENCE (2020)
Perturbing proteomes at single residue resolution using base editing
Philippe C. Despres et al.
NATURE COMMUNICATIONS (2020)
Combinatorial single-cell CRISPR screens by direct guide RNA capture and targeted sequencing
Joseph M. Replogle et al.
NATURE BIOTECHNOLOGY (2020)
Determinants of Base Editing Outcomes from Target Library Analysis and Machine Learning
Mandana Arbab et al.
CELL (2020)
Sequence-specific prediction of the efficiencies of adenine and cytosine base editors
Myungjae Song et al.
NATURE BIOTECHNOLOGY (2020)
Single-cell analysis of a mutant library generated using CRISPR-guided deaminase in human melanoma cells
Soyeong Jun et al.
COMMUNICATIONS BIOLOGY (2020)
CRISPResso2 provides accurate and rapid genome editing sequence analysis
Kendell Clement et al.
NATURE BIOTECHNOLOGY (2019)
Engineered CRISPR-Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing
Benjamin P. Kleinstiver et al.
NATURE BIOTECHNOLOGY (2019)
Next-generation characterization of the Cancer Cell Line Encyclopedia
Mahmoud Ghandi et al.
NATURE (2019)
miR-103/107 prolong Wnt/β-catenin signaling and colorectal cancer stemness by targeting Axin2
Hsin-Yi Chen et al.
SCIENTIFIC REPORTS (2019)
STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets
Damian Szklarczyk et al.
NUCLEIC ACIDS RESEARCH (2019)
Ensembl 2019
Fiona Cunningham et al.
NUCLEIC ACIDS RESEARCH (2019)
Recommendations for the collection and use of multiplexed functional data for clinical variant interpretation
Hannah Gelman et al.
GENOME MEDICINE (2019)
Orthologous CRISPR-Cas9 enzymes for combinatorial genetic screens
Fadi J. Najm et al.
NATURE BIOTECHNOLOGY (2018)
ClinVar: improving access to variant interpretations and supporting evidence
Melissa J. Landrum et al.
NUCLEIC ACIDS RESEARCH (2018)
Mapping the Genetic Landscape of Human Cells
Max A. Horlbeck et al.
CELL (2018)
Base-specific mutational intolerance near splice sites clarifies the role of nonessential splice nucleotides
Sidi Zhang et al.
GENOME RESEARCH (2018)
Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction
Luke W. Koblan et al.
NATURE BIOTECHNOLOGY (2018)
Target identification of small molecules using large-scale CRISPR-Cas mutagenesis scanning of essential genes
Jasper Edgar Neggers et al.
NATURE COMMUNICATIONS (2018)
Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance
Stephen J. Pettitt et al.
NATURE COMMUNICATIONS (2018)
Functional Genetic Variants Revealed by Massively Parallel Precise Genome Editing
Eilon Sharon et al.
CELL (2018)
Accurate classification of BRCA1 variants with saturation genome editing
Gregory M. Findlay et al.
NATURE (2018)
CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions
Michal Zimmermann et al.
NATURE (2018)
Engineered CRISPR-Cas9 nuclease with expanded targeting space
Hiroshi Nishimasu et al.
SCIENCE (2018)
Programmable base editing of A.T to G.C in genomic DNA without DNA cleavage
Nicole M. Gaudelli et al.
NATURE (2017)
Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions
Kyuho Han et al.
NATURE BIOTECHNOLOGY (2017)
Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions
Y. Bill Kim et al.
NATURE BIOTECHNOLOGY (2017)
CRISPR-STOP: gene silencing through base-editing-induced nonsense mutations
Cem Kuscu et al.
NATURE METHODS (2017)
Creation of Novel Protein Variants with CRISPR/Cas9-Mediated Mut agenesis: Turning a Screening By-Product into a Discovery Tool
Katherine F. Donovan et al.
PLOS ONE (2017)
Variant Interpretation: Functional Assays to the Rescue
Lea M. Starita et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2017)
The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models
Andras Kotschy et al.
NATURE (2016)
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
Alexis C. Komor et al.
NATURE (2016)
Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
John G. Doench et al.
NATURE BIOTECHNOLOGY (2016)
Targeted AIDID-mediated mutagenesis (TAM) enables efficient genomic diversification in mammalian cells
Yunqing Ma et al.
NATURE METHODS (2016)
Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells
Gaelen T. Hess et al.
NATURE METHODS (2016)
The Ensembl Variant Effect Predictor
William McLaren et al.
GENOME BIOLOGY (2016)
High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities
Traver Hart et al.
CELL (2015)
PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain
Jennine M. Dawicki-McKenna et al.
MOLECULAR CELL (2015)
Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy
Joel D. Leverson et al.
SCIENCE TRANSLATIONAL MEDICINE (2015)
Hypomyelination with atrophy of the basal ganglia and cerebellum: further delineation of the phenotype and genotype-phenotype correlation
Eline M. Hamilton et al.
BRAIN (2014)
Synonymous Mutations Frequently Act as Driver Mutations in Human Cancers
Fran Supek et al.
CELL (2014)
Discovery and Structure-Activity Relationship of Novel 2,3-Dihydrobenzofuran-7-carboxamide and 2,3-Dihydrobenzofuran-3(2H)-one-7-carboxamide Derivatives as Poly(ADP-ribose)polymerase-1 Inhibitors
Maulik R. Patel et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Measuring error rates in genomic perturbation screens: gold standards for human functional genomics
Traver Hart et al.
MOLECULAR SYSTEMS BIOLOGY (2014)
Saturation editing of genomic regions by multiplex homology-directed repair
Gregory M. Findlay et al.
NATURE (2014)
Improved vectors and genome-wide libraries for CRISPR screening
Neville E. Sanjana et al.
NATURE METHODS (2014)
Comprehensive mutational scanning of a kinase in vivo reveals substrate-dependent fitness landscapes
Alexandre Melnikov et al.
NUCLEIC ACIDS RESEARCH (2014)
Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
Ophir Shalem et al.
SCIENCE (2014)
Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity
Zhi-Fu Tao et al.
ACS MEDICINAL CHEMISTRY LETTERS (2014)
Chromosome territories reposition during DNA damage-repair response
Ishita S. Mehta et al.
GENOME BIOLOGY (2013)
Disruption of gap junctions attenuates aminoglycoside-elicited renal tubular cell injury
Jian Yao et al.
BRITISH JOURNAL OF PHARMACOLOGY (2010)
High-resolution analysis of DNA regulatory elements by synthetic saturation mutagenesis
Rupali P. Patwardhan et al.
NATURE BIOTECHNOLOGY (2009)
The chemical genomic portrait of yeast: Uncovering a phenotype for all genes
Maureen E. Hillenmeyer et al.
SCIENCE (2008)
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
H Farmer et al.
NATURE (2005)
Comparison of the differential context-dependence of DNA deamination by APOBEC enzymes:: Correlation with mutation spectra in vivo
RCL Beale et al.
JOURNAL OF MOLECULAR BIOLOGY (2004)
Cleavage of Mcl-1 by caspases impaired its ability to counteract Bim-induced apoptosis
M Herrant et al.
ONCOGENE (2004)
Characterisation of Mcl-1 cleavage during apoptosis of haematopoietic cells
JG Clohessy et al.
BRITISH JOURNAL OF HAEMATOLOGY (2004)
Lentivirus-delivered stable gene silencing by RNAi in primary cells
SA Stewart et al.
RNA (2003)
Cancer-predisposing mutations within the RING domain of BRCA1: Loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity
H Ruffner et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)