Journal
CARDIOVASCULAR TOXICOLOGY
Volume 21, Issue 4, Pages 265-271Publisher
HUMANA PRESS INC
DOI: 10.1007/s12012-021-09638-1
Keywords
Parenteral nutrition; Endothelial nitric oxide synthase; Reactive oxygen species; Tetrahydrobiopterin
Categories
Funding
- National Institutes of Health [K08DK098623, R03EB015955-01]
- DeNardo Foundation
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Parenteral nutrition is a life-saving nutritional therapy, but it can cause various side effects, especially liver disease. The adverse effects of PN on organ systems such as the brain and cardiovascular system are poorly studied.
Parenteral nutrition (PN) is a life-saving nutritional therapy for those situations when patients are unable to receive enteral nutrition. However, despite a multitude of benefits offered by PN, it is associated with a variety of side effects, most notably parenteral nutrition-associated liver disease (PNALD). Adverse effects of PN on other organ systems, such as brain and cardiovascular system, have been poorly studied. There have been several case reports, studies, and a recent animal study highlighting cardiotoxic effects of PN; however, much remains unclear about the underlying mechanisms causing cardiac damage. In this review, we propose a series of potential mechanisms behind PN-associated heart injury, and we provide an overview of therapeutic strategies and recent scientific advances.
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