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Matrix vesicles: Are they anchored exosomes?

Journal

BONE
Volume 79, Issue -, Pages 29-36

Publisher

ELSEVIER SCIENCE INC
DOI: 10.1016/j.bone.2015.05.013

Keywords

Matrix vesicle; Mineralization; Chondrocyte; Osteoblast; Growth plate; Exosome

Funding

  1. National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health [R01-AR050087, R01-AR055655, R01-AR060228]

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Numerous studies have documented that matrix vesicles are unique extracellular membrane-bound microparticles that serve as initial sites for mineral formation in the growth plate and most other vertebrate mineralizing tissues. Microparticle generation is not confined to hard tissues, as cells in soft tissues generate similar structures; numerous studies have shown that a common type of extracellular particle, termed an exosome, a product of the endosomal pathway, shares many characteristics of matrix vesicles. Indeed, analyses of size, morphology and lipid and protein content indicate that matrix vesicles and exosomes are homologous structures. Such a possibility impacts our understanding of the biogenesis, processing and function of matrix vesicles (exosomes) in vertebrate hard tissues and explains in part how cells control the earliest stages of mineral deposition. Moreover, since exosomes influence a spectrum of functions, including cell-cell communication, it is suggested that this type of microparticle may provide a mechanism for the transfer of signaling molecules between cells within the growth plate and thereby regulate endochondral bone development and formation. (C) 2015 Elsevier Inc. All rights reserved.

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