Journal
CARBOHYDRATE POLYMERS
Volume 254, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2020.117421
Keywords
Phosphorylated cellulose microspheres; Esterification reaction; Ciprofloxacin loading and releasing
Categories
Funding
- National Natural Science Foundation of China [51773159]
- Special Projects of the Central Government in Guidance of Local Science and Technology Development in Hubei Province [2020ZYYD040]
- second batch of the Key Research and Development Project of Hubei Province [2020BAB073]
- Outstanding Young and Middle-aged Scientific Innovation Team of Colleges and Universities of Hubei Province: Biomass chemical technologies and materials [T201908]
- Open Project of Key Laboratory of Green Chemical Process of Ministry of Education [GCP20200206]
- Hubei Key Laboratory of Novel Reactor and Green Chemical Technology (Wuhan Institute of Technology) [K202002]
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Functionalized phosphorylated cellulose microspheres (CMP) were designed as a carrier for ciprofloxacin (CIP) drug delivery system, successfully incorporating and releasing CIP with a significant antibacterial effect. This study provides insight into the design of suitable cellulose microspheres for CIP delivery.
In this work, functionalized phosphorylated cellulose microspheres (CMP) were designed as a carrier for the ciprofloxacin (CIP) drug delivery system. The CMP has been developed from cellulose microspheres (CM) and phosphoric acid via an esterification reaction. CIP, an antibiotic drug as a model, was loaded onto CIP via hydrogen bonds and electrostatic interactions. A series of test results showed that the CIP was successfully incorporated and released from the prepared CMP without the loss of structural integrity or changing its functionality. The release kinetics and mechanism suggest that CIP release follows first-order kinetics and non-Fickian diffusion mechanism. The cytotoxicity behavior of CMP enables the material as a suitable vehicle for the safe release of CIP. The CIP loaded microspheres exhibited a significant antibacterial effect due to the CIP release and diffusion from the microspheres. This study provides insight into the design of suitable cellulose microspheres for CIP delivery.
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