Journal
CARBOHYDRATE POLYMERS
Volume 254, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2020.117189
Keywords
Polysaccharides; Ulcerative colitis; Pathogenesis; Signal pathway; Therapeutic mechanism
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Funding
- 'Six Major Talent Peak Project' of Jiangsu province [2015-YY-011, BE2019767]
- '333 Engineering' Research Project of Jiangsu Province [BRA2015494]
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Ulcerative colitis (UC) has a high incidence rate and there is an urgent need for a new drug that can safely and effectively treat it. Recent studies on polysaccharides from natural resources have shown that they can regulate inflammatory cytokines, intestinal flora, and immune system, protecting the intestinal mucosa.
The incidence of ulcerative colitis (UC) is high. Despite the availability of various therapeutic agents for the treatment of UC, the routine treatment has limitations and serious side effects. Therefore, a new drug that safely and effectively treats UC is urgently needed. Polysaccharides from natural resources have recently become a hot topic of study for their therapeutic effects on UC. These effects are associated with the regulation of inflammatory cytokines, intestinal flora, and immune system and protection of the intestinal mucosa. This review focuses on the recent advances of polysaccharides from natural resources in the treatment of UC. The mechanisms and practicability of polysaccharides, including pectin, guar gum, rhamnogalacturonan, chitosan, fructan, psyllium, glycosaminoglycan, algal polysaccharides, polysaccharides from fungi and traditional Chinese medicine, and polysaccharide derivatives, are discussed in detail. The good efficacy and safety of polysaccharides make them promising drugs for treating UC.
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