Stimuli-responsive natural gums-based drug delivery systems for cancer treatment

Chemotherapy as the main cancer treatment method has non-specific effects and various side-effects. Accordingly, significant attempts have been conducted to enhance its efficacy through design and development of smart drug delivery systems (DDSs). In this context, natural gums, as a nice gift by the nature, can be exploited as stimuli-responsive DDSs for cancer treatment in part due to their renewability, availability, low cost, bioactivity, biocompatibility, low immunogenicity, biodegradability, and acceptable stability in both in vitro and in vivo conditions. However, some shortcomings (e.g., poor mechanical properties and high hydration rate) restrict their biomedical application ranges that can be circumvented through modification process (e.g., grafting of stimuli-responsive polymers or small molecules) to obtain tailored biomaterials. This review article aimed to compile the stimuli-responsive DDSs based on natural gums. In addition, different types of stimuli, the fundamental features of natural gums, as well as their chemical modification approaches are also shortly highlighted.

Automated summary

Natural gums can be utilized as stimuli-responsive DDSs for cancer treatment due to their beneficial characteristics, though they may require modification to overcome certain limitations. This review article aims to compile natural gums-based stimuli-responsive DDSs and briefly highlight different types of stimuli, fundamental features of natural gums, and chemical modification approaches.