Journal
CANCER LETTERS
Volume 499, Issue -, Pages 85-98Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2020.12.003
Keywords
Erythroid cells; Immune tolerance; Hepatocellular carcinoma; Prognosis
Categories
Funding
- National Natural Science Foundation of China [81972677, 81700645]
- Guangdong Basic and Applied Basic Research Foundation [2019A1515012198, 2017A030313537]
- Guangzhou Science and Technology Project [201904010461]
- Special Fundamental Research Fund of Sun Yat-sen University [19ykpy17]
- National Special Research Program of China for Important Infectious Diseases [2018ZX10302103, 2017ZX10202102]
- Important Key Program of the Natural Science Foundation of China [81730060]
- Tip-top Scientific and Technical Innovative Youth Talents of Guangdong Special Support Program [2019TQ05Y266]
Ask authors/readers for more resources
The study revealed that an accumulation of CD45(+)CD71(+) erythroid cells in HCC tissues could play a superior immunosuppressive role in the tumor microenvironment. They suppress T cells through generation of reactive oxygen species, IL-10, and TGF-beta, and their abundance in tumor tissue may serve as a valuable biomarker to predict HCC recurrence, with a prognostic value better than conventional scoring systems.
CD45(+)CD71(+) erythroid cells generated through splenic extramedullary erythropoiesis have recently been found to suppress anti-infection and tumor immunity in neonates and adults with malignances. However, their role in tumor microenvironment has not been investigated. In the present study, we found that the number of CD45(+)CD71(+) erythroid cells was significantly elevated in hepatocellular carcinoma (HCC) tissues compared to that in paratumor region and circulation. Additionally, they were more abundant in HCC tissues compared to some immune suppressive cells as well as CD45(-)CD71(+) erythroid cells. CD45(+)CD71(+) erythroid cells suppressed T cells through generation of reactive oxygen species, IL-10, and TGF-beta in a paracrine and cell-cell contact manner, and their suppressive effect was stronger than that of myeloid-derived suppressor cells. The abundance of CD45(+)CD71(+) erythroid cells in tumor tissue, as illustrated via immunofluorescence, predicted disease-free survival and overall survival, and its prognostic value was better than that of Cancer of the Liver Italian Program score. This study demonstrated that accumulation of intratumoral CD45(+)CD71(+) erythroid cells in HCC tissues could play a superior immunosuppressive role in tumor microenvironment and may serve as a valuable biomarker to predict recurrence of HCC.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available