Journal
CANCER CELL INTERNATIONAL
Volume 21, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12935-021-01853-8
Keywords
Multicellular tumor spheroids; Drug screening; Therapeutic efficacy; High-throughput; Microfluidics
Categories
Funding
- National Research Foundation of Korea (NRF) - Korea government (MSIT) [2020R1F1A1057505]
- National Research Foundation of Korea [2020R1F1A1057505] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The three-dimensional multicellular tumor spheroids model has great potential for cancer research, resembling in vivo solid tumors in many aspects and providing a platform for studying biological properties of tumors and drug screening. However, challenges in adoption for preclinical studies remain to be addressed.
The three-dimensional (3D) multicellular tumor spheroids (MCTs) model is becoming an essential tool in cancer research as it expresses an intermediate complexity between 2D monolayer models and in vivo solid tumors. MCTs closely resemble in vivo solid tumors in many aspects, such as the heterogeneous architecture, internal gradients of signaling factors, nutrients, and oxygenation. MCTs have growth kinetics similar to those of in vivo tumors, and the cells in spheroid mimic the physical interaction of the tumors, such as cell-to-cell and cell-to-extracellular matrix interactions. These similarities provide great potential for studying the biological properties of tumors and a promising platform for drug screening and therapeutic efficacy evaluation. However, MCTs are not well adopted as preclinical tools for studying tumor behavior and therapeutic efficacy up to now. In this review, we addressed the challenges with MCTs application and discussed various efforts to overcome the challenges.
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