Journal
EMBO MOLECULAR MEDICINE
Volume 8, Issue 3, Pages 232-246Publisher
WILEY
DOI: 10.15252/emmm.201505610
Keywords
brown adipose tissue; glucose uptake; mTORC2; thermogenesis
Categories
Funding
- Ministerio de Economia y Competitividad
- Plan Nacional I+D+I (SAF) [2014-54866-R]
- Generalitat de Catalunya, Spain [2014 SGR 1669]
- Generalitat de Catalunya (ICREA Academia), Spain
- Swiss National Science Foundation
- Louis Jeantet Foundation
- Werner Siemens Foundation (VA)
- Canton of Basel
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Activation of non-shivering thermogenesis (NST) in brown adipose tissue (BAT) has been proposed as an anti-obesity treatment. Moreover, cold-induced glucose uptake could normalize blood glucose levels in insulin-resistant patients. It is therefore important to identify novel regulators of NST and cold-induced glucose uptake. Mammalian target of rapamycin complex 2 (mTORC2) mediates insulin-stimulated glucose uptake in metabolic tissues, but its role in NST is unknown. We show that mTORC2 is activated in brown adipocytes upon -adrenergic stimulation. Furthermore, mice lacking mTORC2 specifically in adipose tissue (AdRiKO mice) are hypothermic, display increased sensitivity to cold, and show impaired cold-induced glucose uptake and glycolysis. Restoration of glucose uptake in BAT by overexpression of hexokinase II or activated Akt2 was sufficient to increase body temperature and improve cold tolerance in AdRiKO mice. Thus, mTORC2 in BAT mediates temperature homeostasis via regulation of cold-induced glucose uptake. Our findings demonstrate the importance of glucose metabolism in temperature regulation.
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