Journal
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
Volume 49, Issue 1, Pages 123-128Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/cjn.2021.42
Keywords
Parkinson's disease; Foot dystonia; Botulinum toxin A; Gait
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Funding
- National Key Research and Development Program [2016YFC1306505]
- National Natural Science Foundation of China [81870887, 81873778, 81501097, 81801267]
- Shanghai Municipal Commission of Health and Family Planning [201840001]
- Shanghai Municipal Education Commission-Basic Key Project [18JC1420300]
- Shanghai Clinical Collaboration Construction Project of Chinese and Western Medicine [ZY20182020-FWTX-1104]
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This study investigated the effects of botulinum toxin on gait in Parkinson's disease patients with foot dystonia. The results showed that botulinum toxin improved the severity of dystonia, reduced pain, and improved foot pressures during walking.
We investigated the effects of botulinum toxin on gait in Parkinson's disease (PD) patients with foot dystonia. Six patients underwent onabotulinum toxin A injection and were assessed by Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS), visual analog scale (VAS) of pain, Timed Up and Go (TUG), Berg Balance Test (BBT), and 3D gait analysis at baseline, 1 month, and 3 months. BFMDRS (p = 0.002), VAS (p = 0.024), TUG (p = 0.028), and BBT (p = 0.034) were improved. Foot pressures at Toe 1 (p = 0.028) and Midfoot (p = 0.018) were reduced, indicating botulinum toxin's effects in alleviating the dystonia severity and pain and improving foot pressures during walking in PD.
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