Journal
CANADIAN JOURNAL OF CHEMICAL ENGINEERING
Volume 99, Issue 10, Pages 2069-2086Publisher
WILEY
DOI: 10.1002/cjce.24094
Keywords
biomaterials; bioreactors; cell delivery; rheology; tissue engineering
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Funding
- Natural Sciences and Engineering Research Council (NSERC) of Canada
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Tissue engineering and regenerative medicine have advanced significantly over the past 30 years, with key modules including cells, biodegradable scaffolds, bioreactors, and biomolecules. These fields involve various disciplines such as biological sciences, chemical engineering, materials chemistry, and polymer processing, requiring a deep understanding of viscous fluid flow, mass transfer, and reaction engineering.
Since its emergence nearly 30 years ago with the goal of fabricating replacement human tissues or assisting the body in repairing itself, several advances have been made in the fields of tissue engineering and regenerative medicine. The assembly of living cells into tissues is akin to the scale-up operation of a chemical or biochemical process with several modules or units affecting the final product. The major modules or units in tissue engineering and regenerative medicine are cells, biodegradable scaffolds, bioreactors, and biomolecules. Each module is analogous to unit operations, where individual units must come together to successfully design engineered tissues for therapeutic and drug discovery applications. Basic principles of biological sciences, chemical engineering, materials chemistry, and polymer processing are frequently employed. More specifically, knowledge about viscous fluid flow, mass transfer, and reaction engineering is essential in tissue engineering. In this review article, we present the nexus between chemical engineering and tissue engineering for the rational design of engineered tissues or injectable cell-laden hydrogel systems.
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