Journal
EMBO JOURNAL
Volume 35, Issue 6, Pages 561-579Publisher
WILEY
DOI: 10.15252/embj.201593564
Keywords
autophagy; endolysosomal system; membrane traffic; phosphatidylinositol 3-phosphate; signalling
Categories
Funding
- Alexander von Humboldt Foundation
- Banting Postdoctoral Fellowships
- German Research Foundation [SFB740/C08]
Ask authors/readers for more resources
Phosphoinositides (PIs) form a minor class of phospholipids with crucial functions in cell physiology, ranging from cell signalling and motility to a role as signposts of compartmental membrane identity. Phosphatidylinositol 3-phosphates are present at the plasma membrane and within the endolysosomal system, where they serve as key regulators of both cell signalling and of intracellular membrane traffic. Here, we provide an overview of the metabolic pathways that regulate cellular synthesis of PI 3-phosphates at distinct intracellular sites and discuss the mechanisms by which these lipids regulate cell signalling and membrane traffic. Finally, we provide a framework for how PI 3-phosphate metabolism is integrated into the cellular network.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available