Journal
BONE
Volume 70, Issue -, Pages 28-36Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bone.2014.07.028
Keywords
MSC; Osteoblast differentiation; Dlk1; Pref-1; Lrp5; Kinases
Categories
Funding
- Danish Medical Research Council [12-126231]
- Novo Nordisk Foundation [5047]
- King Abdullah City for Science and Technology (KACST), KSA [10-BIO1308-02]
- Novo Nordisk Fonden [NNF15CC0018344, NNF14OC0010309, NNF13OC0005047] Funding Source: researchfish
Ask authors/readers for more resources
Skeletal (marrow stromal) stem cells (BMSCs) are a group of multipotent cells that reside in the bone marrow stroma and can differentiate into osteoblasts, chondrocytes and adipocytes. Studying signaling pathways that regulate BMSC differentiation into osteoblastic cells is a strategy for identifying druggable targets for enhancing bone formation. This review will discuss the functions and the molecular mechanisms of action on osteoblast differentiation and bone formation; of a number of recently identified regulatory molecules: the non-canonical Notch signaling molecule Delta-like l/preadipocyte factor 1 (Dlk1/Pref-1), the Wnt co-receptor Lrp5 and intracellular kinases. This article is part of a Special Issue entitled: Stem Cells and Bone. (C) 2014 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available