Journal
BRIEFINGS IN FUNCTIONAL GENOMICS
Volume 20, Issue 2, Pages 94-105Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bfgp/elab003
Keywords
non-coding RNA; epitranscriptomics; RNA epigenetics; cancer; RNA modifications; RNA methylation
Funding
- IIT funding
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Post-synthesis modification is an efficient way to regulate and optimize the functions of biomolecules. Modifications of non-coding RNAs can directly affect their structure and function, playing a crucial role in cancer.
Post-synthesis modification of biomolecules is an efficient way of regulating and optimizing their functions. The human epitranscriptome includes a variety of more than 100 modifications known to exist in all RNA subtypes. Modifications of non-coding RNAs are particularly interesting since they can directly affect their structure, stability, interaction and function. Indeed, non-coding RNAs such as tRNA and rRNA are the most modified RNA species in eukaryotic cells. In the last 20 years, new functions of non-coding RNAs have been discovered and their involvement in human disease, including cancer, became clear. In this review, we will present the evidence connecting modifications of different non-coding RNA subtypes and their role in cancer.
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