4.2 Editorial Material

Special issue on sporotrichosis: challenges to deal with the new emerging pathogenic species

Related references

Note: Only part of the references are listed.
Article Microbiology

Susceptibility and resistance of Sporothrix brasiliensis to branded and compounded itraconazole formulations

Stefanie Bressan Waller et al.

Summary: The study evaluated the in vitro efficacy and content of itraconazole formulations for treating sporotrichosis, finding varying effectiveness and widespread antifungal resistance among tested isolates. Susceptibility testing is necessary when choosing a product, and strict quality control measures are recommended for drug manufactures.

BRAZILIAN JOURNAL OF MICROBIOLOGY (2021)

Review Microbiology

Feline sporotrichosis in Asia

Hock Siew Han et al.

Summary: Sporothrix schenckii sensu lato is a species complex with only certain strains identified to cause disease in cats. Feline sporotrichosis in Asia is mainly reported from Malaysia, with a need for further molecular epidemiological studies due to lack of data. The prognosis for the disease is guarded to poor due to various factors such as cost, treatment course, zoonotic potential, and low susceptibility to antifungals.

BRAZILIAN JOURNAL OF MICROBIOLOGY (2021)

Article Microbiology

Human serum proteins bind to Sporothrix schenckii conidia with differential effects on phagocytosis

Silvia Guzman Beltran et al.

Summary: The study identified human serum proteins, including SAP and α-1 antitrypsin, that activate macrophage phagocytosis of S. schenckii conidia. Transferrin and albumin, on the other hand, showed no effect on conidia internalization.

BRAZILIAN JOURNAL OF MICROBIOLOGY (2021)

Article Microbiology

Evolution of virulence-related phenotypes of Sporothrix brasiliensis isolates from patients with chronic sporotrichosis and acquired immunodeficiency syndrome

Ingrid Ludmila Rodrigues Cruz et al.

Summary: This study aims to compare sequential Sporothrix isolates obtained from patients with sporotrichosis and AIDS in order to detect changes in virulence-related phenotypes and acquisition of antifungal resistance during the evolution of the disease. The results showed changes in all studied phenotypes during the course of the disease in some patients.

BRAZILIAN JOURNAL OF MICROBIOLOGY (2021)

Article Microbiology

Feline sporotrichosis: a case series of itraconazole-resistant Sporothrix brasiliensis infection

Ceres Cristina Tempel Nakasu et al.

Summary: This study revealed the therapeutic history of cats infected with itraconazole-resistant Sporothrix brasiliensis in an endemic region of Southern Brazil, highlighting treatment abandonment and medication errors as major challenges in achieving clinical healing. The need for antifungal susceptibility tests to guide therapeutic protocols in feline sporotrichosis was emphasized.

BRAZILIAN JOURNAL OF MICROBIOLOGY (2021)

Article Microbiology

Seroepidemiological survey on sporotrichosis-infection in rural areas of the south of Minas Gerais State, Brazil

Julianne Caravita Grisoli et al.

Summary: Sporotrichosis is a subcutaneous mycosis caused by fungi species of the genus Sporothrix, most prevalent in tropical and subtropical countries, with higher frequency in Brazil. A study in southern Minas Gerais State, Brazil, found a high seroprevalence of sporotrichosis in rural regions, with no significant difference in prevalence with respect to gender and age, highlighting the importance of understanding disease distribution for effective prevention and control measures.

BRAZILIAN JOURNAL OF MICROBIOLOGY (2021)

Review Microbiology

Antifungal resistance on Sporothrix species: an overview

Stefanie Bressan Waller et al.

Summary: The study revealed the emergence of Sporothrix species with in vitro antifungal resistance, possibly due to mechanisms such as melanin production capacity, genetic diversity, and mutations in cytochrome P450. Further research targeting gene expression is needed to identify new therapeutic targets for human and veterinary use.

BRAZILIAN JOURNAL OF MICROBIOLOGY (2021)

Article Microbiology

Canine sporotrichosis: polyphasic taxonomy and antifungal susceptibility profiles ofSporothrixspecies in an endemic area in Brazil

Jessica Sepulveda Boechat et al.

Summary: This study characterized canine isolates ofSporothrixfrom Brazil and found that most wereS. brasiliensis, with oneS. schenckii. All isolates showed effective in vitro antifungal activity against commonly used drugs.

BRAZILIAN JOURNAL OF MICROBIOLOGY (2021)

Article Microbiology

Anti-Sporothrixactivity of ibuprofen combined with antifungal

Luana Pereira Borba-Santos et al.

Summary: Ibuprofen enhances the in vitro activity of antifungals, mainly amphotericin B, against Sporothrix brasiliensis and S. schenckii. The combination therapy shows a more significant effect on fungal growth inhibition. Further in vivo studies are needed to confirm the efficacy of ibuprofen in combination with antifungals in animal models.

BRAZILIAN JOURNAL OF MICROBIOLOGY (2021)

Article Microbiology

In vitro antifungal susceptibility ofSporothrix globosaisolates from Jilin Province, northeastern China: comparison of yeast and mycelial phases

Yang Song et al.

Summary: This study evaluated the susceptibility of 80 isolates ofS. globosa from Jilin Province, China, to six antifungal agents. The results showed that the isolates were most sensitive to terbinafine, posaconazole, and itraconazole, while relatively resistant to fluconazole and voriconazole. Additionally, the sensitivities ofS. globosa to antifungal compounds were found to be dependent on incubation temperature and growth phase.

BRAZILIAN JOURNAL OF MICROBIOLOGY (2021)

Article Microbiology

Geographical distribution and ecological niche modeling of the etiological agents of human sporotrichosis in Venezuela

Laura Barreto et al.

Summary: The study established the geographical distribution and ecological niche of two Sporothrix species in Venezuela, S. schenckii and S. globosa. Molecular taxonomy analysis and niche modeling revealed altitude, temperature, and land use as key factors influencing the distribution of these fungi.

BRAZILIAN JOURNAL OF MICROBIOLOGY (2021)

Article Microbiology

Phenotypic and molecular characterisation ofSporothrix globosaof diverse origin from India

Shivaprakash M. Rudramurthy et al.

Summary: Sporotrichosis caused by thermally dimorphic fungi is a neglected tropical disease, withSporothrix globosabeing the most common pathogenic species in Asian countries. A study on 63 cases from India found that all isolates wereS. globosa, with specific growth and assimilation characteristics. Molecular characterization and antifungal susceptibility testing helped differentiate different species, with some antifungals showing good activity againstS. globosa. No correlation was found between genotypes and clinical presentation or geographic distribution.

BRAZILIAN JOURNAL OF MICROBIOLOGY (2021)

Article Microbiology

Sporothrix globosamelanin inhibits antigenpresentation by macrophages and enhances deep organ dissemination

Yang Song et al.

Summary: Melanin from Sporothrix globosa can inhibit the expression of antigen presentation-associated molecules in macrophages, affecting host immune response and enhancing fungal dissemination. The study suggests that melanin has inhibitory effects on antigen presentation during both the early and late stages of infection.

BRAZILIAN JOURNAL OF MICROBIOLOGY (2021)

Article Microbiology

Promising application of the SsCBF ELISA test to monitor the therapeutic response of feline sporotrichosis caused bySporothrix brasiliensisfrom Brazilian epidemics

Vivian S. Baptista et al.

Summary: The study suggests that sporotrichosis zoonotic transmission by cats has reached a high level of local transmission in Rio de Janeiro, Brazil. The SsCBF ELISA test is found to be valuable for predicting therapeutic responses in feline sporotrichosis.

BRAZILIAN JOURNAL OF MICROBIOLOGY (2021)

Review Microbiology

Guideline for the management of feline sporotrichosis caused bySporothrix brasiliensisand literature revision

Isabella Dib Ferreira Gremiao et al.

Summary: This guideline, created by a national technical group organized by the Working Group on Sporothrix and Sporotrichosis of ISHAM, aims to provide information on clinical-epidemiological aspects of feline sporotrichosis, as well as a literature review. It also includes practical information on diagnosis and treatment, as well as guidance on prevention and control of S. brasiliensis transmission.

BRAZILIAN JOURNAL OF MICROBIOLOGY (2021)

Review Microbiology

Sporotrichosis in Mexico

Conchita Toriello et al.

Summary: Sporotrichosis, caused by species of the Sporothrix genus, is considered one of the most common subcutaneous mycoses in Mexico. The disease usually presents as the lymphocutaneous form in males aged 0-15, with trauma from plants being the most common source of infection. Laboratory diagnosis in Mexico mainly relies on conventional methods, while treatment choice depends on the clinical form, host's immune status, and Sporothrix species involved. Public awareness and reporting of sporotrichosis in Mexico are limited.

BRAZILIAN JOURNAL OF MICROBIOLOGY (2021)