Journal
BMC PEDIATRICS
Volume 21, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12887-021-02539-w
Keywords
Children; Gut microbiota; Polycyclic aromatic hydrocarbons; Neurodevelopment
Categories
Funding
- National Natural Science Foundation of China [81372955]
- Qingdao Outstanding Health Professional Development Fund
- Qingdao Key Health Discipline Development Fund
- projects of medical and health technology development program in Shandong province [2016WS0309]
- BiosTime Maternal and Infant Nutrition and Health Research Fund [2017FYH008]
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The composition of the GM is associated with neurodevelopment in children, and PAHs appear to alter the relative abundance of some taxa to counteract the negative effects of the PAHs.
BackgroundDuring the second and third year after birth the gut microbiota (GM) is subjected to important development. The polycyclic aromatic hydrocarbon (PAH) exposure could influence the GM in animal and early postnatal exposure is associated with neurodevelopment disorder in children. This study was designed to explore the possible influence of the polycyclic aromatic hydrocarbons (PAHs) on the composition of the gut microbiota (GM) and neurodevelopment in a sample of 38 healthy children at the age of 3years.MethodsA brief development (Gesell Development Inventory, GDI) and behavior test (Child Behavior Checklist, CBCL) were completed on 3-yr-olds and stool samples were collected for 16S rRNA V4-V5 sequencing. The PAH-DNA adduct in the umbilical cord blood and the urinary hydroxyl PAHs (OH-PAHs) at the age of 12months were measured as pre- and postnatal PAH exposure, respectively.ResultsThe most abundant two phyla were Bacteroidetes (68.6%) and Firmicutes (24.2%). The phyla Firmicutes, Actinobacteria, Proteobacteria, Tenericutes, and Lentisphaerae were positively correlated with most domain behaviors of the GDI, whereas the Bacteroidetes, Cyanobacteria, and Fusobacteria were negatively correlated. Correspondingly, the phyla Bacteroidetes, Actinobacteria, and Fusobacteria showed positive correlations with most CBCL core and broadband syndromes, whereas the Firmicutes, Verrucomicrobia, Synergistetes, Proteobacteria and Tenericules were negatively correlated. The OH-PAH levels were not significantly associated with the Firmicutes phylum whereas the Bacteroidetes, Bacteroidia, and Bacteroidales all showed significant negative association with the OH-PAH levels.ConclusionThe current findings suggest that composition of the GM is associated with neurodevelopment of the child. PAHs seem to change the relative abundance of some taxa (some deleted and some recruited) to counteract the negative effects of the PAHs.
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