Journal
BMC INFECTIOUS DISEASES
Volume 21, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12879-021-05845-x
Keywords
COVID-19; Risk factor; Mortality; Nomogram; Fatal outcome
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This study developed a nomogram for clinicians to estimate the risk of in-hospital mortality in COVID-19 patients, which includes factors like age, comorbidities, dyspnea, oxygen saturation, and C-reactive protein. The prediction ability of this nomogram was excellent, which may help reduce mortality in COVID-19 patients through early diagnosis and intervention.
BackgroundOne-fifth of COVID-19 patients are seriously and critically ill cases and have a worse prognosis than non-severe cases. Although there is no specific treatment available for COVID-19, early recognition and supportive treatment may reduce the mortality. The aim of this study is to develop a functional nomogram that can be used by clinicians to estimate the risk of in-hospital mortality in patients hospitalized and treated for COVID-19 disease, and to compare the accuracy of model predictions with previous nomograms.MethodsThis retrospective study enrolled 709 patients who were over 18years old and received inpatient treatment for COVID-19 disease. Multivariable Logistic Regression analysis was performed to assess the possible predictors of a fatal outcome. A nomogram was developed with the possible predictors and total point were calculated.ResultsOf the 709 patients treated for COVID-19, 75 (11%) died and 634 survived. The elder age, certain comorbidities (cancer, heart failure, chronic renal failure), dyspnea, lower levels of oxygen saturation and hematocrit, higher levels of C-reactive protein, aspartate aminotransferase and ferritin were independent risk factors for mortality. The prediction ability of total points was excellent (Area Under Curve=0.922).ConclusionsThe nomogram developed in this study can be used by clinicians as a practical and effective tool in mortality risk estimation. So that with early diagnosis and intervention mortality in COVID-19 patients may be reduced.
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