4.7 Article

Genomic insight into diet adaptation in the biological control agent Cryptolaemus montrouzieri

Journal

BMC GENOMICS
Volume 22, Issue 1, Pages -

Publisher

BMC
DOI: 10.1186/s12864-021-07442-3

Keywords

Genome; Biological control; Ladybird; Cryptolaemus montrouzieri; Prey adaptation; Immunity; Evolution

Funding

  1. National Natural Science Foundation of China [31702012, 31970439]
  2. Science and Technology Planning Project of Guangdong Province, China [2017B020202006]
  3. National Key R&D Program of China [2017YFD0201000]
  4. Basal Research Fund of Sun Yat-sen University [18lgpy50]
  5. Science and Technology Planning Project of Guangzhou, China [201904020041]
  6. Open Project of the State Key Laboratory of Biocontrol [2018-04]

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The ladybird beetle Cryptolaemus montrouzieri has a high-quality genome sequence showing expansions and contractions in certain gene families compared to other beetles. Differences in gene expression on unnatural diets suggest that nutritional deficiencies may explain lower performance. An expansion in immune effector genes in the genome may also play a role in diet adaptation.
Background The ladybird beetle Cryptolaemus montrouzieri Mulsant, 1853 (Coleoptera, Coccinellidae) is used worldwide as a biological control agent. It is a predator of various mealybug pests, but it also feeds on alternative prey and can be reared on artificial diets. Relatively little is known about the underlying genetic adaptations of its feeding habits. Results We report the first high-quality genome sequence for C. montrouzieri. We found that the gene families encoding chemosensors and digestive and detoxifying enzymes among others were significantly expanded or contracted in C. montrouzieri in comparison to published genomes of other beetles. Comparisons of diet-specific larval development, survival and transcriptome profiling demonstrated that differentially expressed genes on unnatural diets as compared to natural prey were enriched in pathways of nutrient metabolism, indicating that the lower performance on the tested diets was caused by nutritional deficiencies. Remarkably, the C. montrouzieri genome also showed a significant expansion in an immune effector gene family. Some of the immune effector genes were dramatically downregulated when larvae were fed unnatural diets. Conclusion We suggest that the evolution of genes related to chemosensing, digestion, and detoxification but also immunity might be associated with diet adaptation of an insect predator. These findings help explain why this predatory ladybird has become a successful biological control agent and will enable the optimization of its mass rearing and use in biological control programs.

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