Journal
BLOOD CELLS MOLECULES AND DISEASES
Volume 86, Issue -, Pages -Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bcmd.2020.102493
Keywords
Cognitive; Anemia; Hypoxia; Memory; Learning; Sickle cell
Categories
Funding
- National Institutes of Health Clinical Center, NIH [1ZIACL090052-01, 1ZIACL090053-01, 1ZIACL090054-01]
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Even without strokes, patients with sickle cell disease may suffer from significant neurocognitive deficits, possibly due to mechanisms unrelated to major cerebrovascular problems. Increased cerebral oxidative stress and stress-induced tissue damage in susceptible brain regions may contribute to neurocognitive deficits in SCD mice.
Strokes are feared complications of sickle cell disease (SCD) and yield significant neurologic and neurocognitive deficits. However, even without detectable strokes, SCD patients have significant neurocognitive deficits in domains of learning and memory, processing speed and executive function. In these cases, mechanisms unrelated to major cerebrovascular abnormalities likely underlie these deficits. While oxidative stress and stress-related signaling pathways play a role in SCD pathophysiology, their role in cerebral injury remains unknown. We have shown that Townes and BERK SCD mice, while not having strokes, recapitulate neurocognitive deficits reported in humans. We hypothesized that cognitive deficits in SCD mice are associated with cerebral oxidative stress. We showed that SCD mice have increased levels of reactive oxygen species, protein carbonylation, and lipid per oxidation in hippocampus and cortex, thus suggesting increased cerebral oxidative stress. Further, cerebral oxidative stress was associated with caspase-3 activity alterations and vascular endothelial abnormalities, white matter changes, and disruption of the blood brain barrier, similar to those reported after ischemic/oxidative injury. Additionally, after repeated hypoxia/reoxygenation exposure, homozygous Townes had enhanced microglia activation. Our findings indicate that oxidative stress and stress-induced tissue damage is increased in susceptible brain regions, which may, in turn, contribute to neurocognitive deficits in SCD mice.
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