Journal
BIOTECHNOLOGY LETTERS
Volume 43, Issue 5, Pages 1005-1018Publisher
SPRINGER
DOI: 10.1007/s10529-021-03089-y
Keywords
Streptomyces; Antimicrobial activity; Column chromatography; Bluemomycin; Cytotoxic studies
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Funding
- King Saud University, Saudi Arabia
- Entomology Research Institute, India
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In this study, a Streptomyces strain with promising antibacterial activity was isolated, leading to the discovery of a new naphthoquinone derivative named bluemomycin. Bluemomycin exhibited potential antibacterial activity against Gram-negative bacteria and showed cytotoxic effects on lung, ovarian, and liver cancer cell lines.
Streptomyces is one of the most prolific producers of economically important bioactive compounds used against several illnesses; it has also been found to produce industrially useful enzymes. In this study, Streptomyces sp. (ERINLG-201) was isolated from the soil sample of Kodanad forest (Southern Western Ghats), The Nilgiris, Tamil Nadu, India. ERINLG-201 isolate showed promising antibacterial activity against tested Gram-positive and Gram-negative bacteria which was confirmed by perpendicular 'T' streak method. Secondary metabolites of ERINLG-201 isolate exhibited promising antibacterial activity against tested Gram-positive and Gram-negative bacteria which was confirmed by disc diffusion method using the ethylacetate extract. Further, the ethylacetate extract of ERINLG-201 (15 g) was packed in column chromatography over silica gel and eluted; it resulted in isolation of a new naphthoquinone derivative named bluemomycin from the active fraction. Bluemomycin showed promising antibacterial activity against Gram-negative bacteria and clinical isolates at least concentration (6.25 mu g/mL). Cytotoxic studies of bluemomycin showed promising activity against A549, Skvo-3 and HepG2 cell lines with IC50 values of 5.9, 24.2 and 11 mu M, respectively. [GRAPHICS] .
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