Journal
BIOSENSORS & BIOELECTRONICS
Volume 176, Issue -, Pages -Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2020.112947
Keywords
Aptamer; Metal-organic frameworks (MOFs); Stimuli-responsive; Microfluidic; Biosensor; Aptasensor
Categories
Funding
- National Institute of Allergy and Infectious Disease of the NIH [R21AI107415]
- U.S. NSF [IIP 1953841, DMR1205302]
- NIH/NIGMS [RL5GM118969, TL4GM118971, UL1GM118970]
- University of Texas at El Paso (UTEP)
- Philadelphia Foundation
- Medical Center of the Americas Foundation
- National Institute of General Medical Sciences of the NIH [SC2GM105584]
- NIH RCMI Pilot Grant
- University of Texas (UT) System
- Multidisciplinary Research Award Program (MRAP)
- URI Program from UTEP
- Dr. Keelung Hong Research Fellowship
- Key Research and Development Project of Shandong Province, China [2019GGX102083]
- Taishan Scholar Program of Shandong Province [ts201511027]
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MOFs, as a class of crystalline porous materials, have been widely applied in various fields due to their nanoscale framework structure, adjustable pore size, large specific surface area, and good chemical stability. With the functionalization of aptamers, MOFs-based biosensors have shown great potential in medical diagnostics, food safety inspection, and environmental surveillance. Researchers are also exploring stimuli-responsive MOFs and the integration of MOFs on microfluidic devices for sensing applications.
As a class of crystalline porous materials, metal-organic frameworks (MOFs) have attracted increasing attention. Due to the nanoscale framework structure, adjustable pore size, large specific surface area, and good chemical stability, MOFs have been applied widely in many fields such as biosensors, biomedicine, electrocatalysis, energy storage and conversions. Especially when they are combined with aptamer functionalization, MOFs can be utilized to construct high-performance biosensors for numerous applications ranging from medical diagnostics and food safety inspection, to environmental surveillance. Herein, this article reviews recent innovations of aptamer-functionalized MOFs-based biosensors and their bio-applications. We first briefly introduce different functionalization methods of MOFs with aptamers, which provide a foundation for the construction of MOFsbased aptasensors. Then, we comprehensively summarize different types of MOFs-based aptasensors and their applications, in which MOFs serve as either signal probes or signal probe carriers for optical, electrochemical, and photoelectrochemical detection, with an emphasis on the former. Given recent substantial research interests in stimuli-responsive materials and the microfluidic lab-on-a-chip technology, we also present the stimuli responsive aptamer-functionalized MOFs for sensing, followed by a brief overview on the integration of MOFs on microfluidic devices. Current limitations and prospective trends of MOFs-based biosensors are discussed at the end.
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