Journal
BIOSENSORS & BIOELECTRONICS
Volume 175, Issue -, Pages -Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2020.112855
Keywords
Self-powered biosensor; Portable biosensor; Glucose detection; Photodetector; Colorimetric assay
Categories
Funding
- Mid-Career Researcher Program through a National Research Foundation grant - Ministry of Science, ICT, and Future Planning [NRF-2017R1A2B3010816]
- Global Frontier Project through BioNano Health-Guard Research Center - Ministry of Science, ICT and Future Planning (MSIP) of Korea [NRF-2019M3A6B2060097]
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A self-powered biosensor using a PEG film was developed for non-invasive glucose detection, eliminating the need for batteries and solutions in assay. The biosensor releases enzymes and color-developing agents from the PEG film for colorimetric assay and can verify target concentration by measuring the photocurrent.
The portability of electronic-based biosensors is limited because of the use of batteries and/or solutions containing reactants such as enzymes for assay, which limits the utility of such biosensors in point-of-care (POC) testing. In this study, we report on the development of a self-powered biosensor composed of only portable components: a reactant-containing poly (ethylene glycol) (PEG) film for the colorimetric assay, and a self-powered n-InGaZnO/p-Si photodetector. The PEG film containing enzymes and color-developing agents was formed on a glass slide by spin coating. The self-powered biosensor was fabricated by placing the hybrid film on the p-n junction photodetector, and applied in non-invasive glucose detection (salivary glucose). Injection of the target-containing solution dissolved the PEG that led to the release of enzymes and color-developing agents, resulting in a colorimetric assay. The colorimetric assay could attenuate the light reaching the photodetector, thus facilitating target concentration verification by measuring the photocurrent. Our self-powered biosensor has two main advantages: (i) all components of the biosensor are portable and (ii) dilution of target concentration is avoided as the reagents are in the PEG film. Therefore, the self-powered biosensor, without solution-phase components, could be highly beneficial for creating portable, sensitive biosensors for POC testing.
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