Journal
BIOSENSORS & BIOELECTRONICS
Volume 175, Issue -, Pages -Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2020.112844
Keywords
MXene-MWCNTs; Wireless RF energy Harvesting; Battery-free; Microfluidics integrated; Flexible biosensor; Human perspiration
Categories
Funding
- Technology Innovation Program - Ministry of Trade, Industry and Energy [20000773]
- Bio & Medical Technology Development Program of the NRF - Korean government (MSIT) [NRF-2017M3A9F1031270]
- Kwangwoon University
- Korea Evaluation Institute of Industrial Technology (KEIT) [20000773] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [4299990114056] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The study developed a new electrochemical sensing patch system for on-site monitoring of potassium ion concentration in human sweat. By utilizing multiwalled carbon nanotube and MXene-Ti3C2TX based hybrid multi-dimensional networks, a high surface activation area and faster charge transfer rate were achieved, accelerating the kinetic process of ion diffusion.
In this study, an ultra-high sensitive, flexible, wireless, battery-free, and fully integrated (no external analysis equipment) electrochemical sensing patch system, including a microfluidic-sweat collecting unit, was newly developed for the on-site monitoring of the [K+] concentration in human sweat. Multiwalled carbon nanotube (MWCNT) and MXene-Ti3C2TX based hybrid multi-dimensional networks were applied to obtain a high surface activation area and faster charge transfer rate, strongly adsorbing the valinomycin membrane to protect the ionophore for effective transshipment and immobilization of the [K+]. Furthermore, the controllable porosity of carbon-based materials can accelerate the kinetic process of ion diffusion. This hybrid nanonetwork structure effectively enhanced electrochemical stability and sensitivity, addressing the noise and signal drifting problems experienced with low concentration detection. The fabricated sensor exhibited a high ion concentration sensitivity of 63 mV/dec with excellent selectivity, amplified to 173 mV/dec with the integrated amplification system. The Near Field Communication (NFC) is used to transmit measurements to a smartphone wirelessly. A microfluidic channel was integrated with the electrochemical sensor patch to efficiently collect sweat on the human skin surface and mitigate the sensor surface contamination problem. Furthermore, the developed sensing patch can also be applied to other biomarkers on-site detection after modifying the working electrode with the corresponding selective membranes.
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