Recent advances in microbial biosynthesis of C3-C5 diols: Genetics and process engineering approaches

Diols derived from renewable feedstocks have significant commercial interest in polymer, pharmaceutical, cosmetics, flavors and fragrances, food and feed industries. In C3-05 diols biological processes of 1,3-propanediol, 1,2-propanediol and 2,3-butanediol have been commercialized as other isomers are non-natural metabolites and lack natural biosynthetic pathways. However, the developments in the field of systems and synthetic biology paved a new path to learn, build, construct, and test for efficient chassis strains. The current review addresses the recent advancements in metabolic engineering, construction of novel pathways, process developments aimed at enhancing in production of C3-05 diols. The requisites on developing an efficient and sustainable commercial bioprocess for C3-05 diols were also discussed.

Automated summary

This review discusses the recent advancements in metabolic engineering, construction of novel pathways, and process developments aimed at enhancing the production of C3-05 diols derived from renewable feedstocks. Also, it addresses the requirements for developing an efficient and sustainable commercial bioprocess for C3-05 diols.