Journal
BONE
Volume 75, Issue -, Pages 105-110Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bone.2015.02.015
Keywords
Osteoporosis; Epidemiology; Body composition; PQCT; Growth; Childhood
Categories
Funding
- Medical Research Council
- British Heart Foundation
- Arthritis Research UK
- National Osteoporosis Society
- International Osteoporosis Foundation
- Cohen Trust
- NIHR Southampton Biomedical Research Centre
- University of Southampton
- University Hospital Southampton NHS Foundation Trust
- NIHR Musculoskeletal Biomedical Research Unit, University of Oxford
- Dunhill Medical Trust
- European Union [289346]
- Arthritis Research UK [20000]
- British Heart Foundation [RG/07/009/23120] Funding Source: researchfish
- Medical Research Council [MC_UU_12011/2, MC_UU_12011/1, U1475000002, MC_UP_A620_1014, MC_U147585819, MC_UP_A620_1015, U1475000001, MC_UU_12011/4, MC_U147585827, MC_UP_A620_1017] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0513-10085, NF-SI-0508-10082, ACF-2014-26-002] Funding Source: researchfish
- Versus Arthritis [17702] Funding Source: researchfish
- MRC [MC_U147585827, MC_UP_A620_1015, MC_UU_12011/2, MC_U147585819, MC_UU_12011/4, MC_UP_A620_1017] Funding Source: UKRI
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Background: Studies in childhood suggest that both body composition and early postnatal growth are associated with bone mineral density (BMD). However, little is known of the relationships between longitudinal changes in fat (FM) and lean mass (LM) and bone development in pre-pubertal children. We therefore investigated these associations in a population-based mother-offspring cohort, the Southampton Women's Survey. Methods: Total FM and LM were assessed at birth and 6-7 years of age by dual-energy x-ray absorptiometry (DXA). At 6-7 years, total cross-sectional area (CSA) and trabecular volumetric BMD (vBMD) at the 4% site (metaphysis) of the tibia was assessed using peripheral quantitative computed tomography [pQCT (Stratec XCT-2000)]. Total CSA, cortical CSA, cortical vBMD and strength-strain index (SSI) were measured at the 38% site (diaphysis). FM, LM and bone parameters were adjusted for age and sex and standardised to create within-cohort z-scores. Change in LM (Delta LM) or FM (Delta FM) was represented by change in z-score from birth to 7 years old and conditioned on the birth measurement. Linear regression was used to explore the associations between Delta LM or Delta FM and standardised pQCT outcomes, before and after mutual adjustment and for linear growth. The /3-coefficient represents SD change in outcome per unit SD change in predictor. Results: DXA at birth, in addition to both DXA and pQCT scans at 6-7 years, were available for 200 children (48.5% male). Delta LM adjusted for Delta FM was positively associated with tibial total CSA at both the 4% (beta = 0.57SD/SD, p < 0.001) and 38% sites (beta = 0.53SD/SD, p < 0.001), cortical CSA (beta = 0.48SD/SD, p < 0.001) and trabecular vBMD (beta = 0.30SD/SD, p < 0.001), but not with cortical vBMD. These relationships persisted after adjustment for linear growth. In contrast, Delta FM adjusted for Delta LM was only associated with 38% total and cortical CSA, which became non-significant after adjustment for linear growth. Conclusion: In this study, gain in childhood LM was positively associated with bone size and trabecular vBMD at 6-7 years of age. In contrast, no relationships between change in FM and bone were observed, suggesting that muscle growth, rather than accrual of fat mass, may be a more important determinant of childhood bone development. (C) 2015 Elsevier Inc. All rights reserved.
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