Phase separation of DNA: From past to present

Phase separation of biological molecules, such as nucleic acids and proteins, has garnered widespread attention across many fields in recent years. For instance, liquid-liquid phase separation has been implicated not only in membraneless intracellular organization but also in many biochemical processes, including transcription, translation, and cellular signaling. Here, we present a historical background of biological phase separation and survey current work on nuclear organization and its connection to DNA phase separation from the perspective of DNA sequence, structure, and genomic context.

Automated summary

Phase separation of biological molecules, such as nucleic acids and proteins, has attracted significant attention in recent years. Liquid-liquid phase separation is involved in membraneless intracellular organization and various biochemical processes. Current research focuses on the connection between nuclear organization and DNA phase separation, considering DNA sequence, structure, and genomic context.