Stereoselective synthesis and discovery of novel spirooxindolopyrrolidine engrafted indandione heterocyclic hybrids as antimycobacterial agents

Novel spirooxindolopyrrolidine embedded indandione heterocyclic hybrids were obtained in excellent yields via a regio- and stereoselective one-pot three component reaction between Baylis-Hillman adduct and non-stabilized azomethine ylides. The structure of newly synthesized compounds was elucidated through 1D and 2D spectroscopic data and the stereochemistry was determined by single crystal X-ray diffraction analysis. In vitro tubercular activity against Mycobacterium tuberculosis H37Rv using MABA assay reveals that the compound bearing chlorine substituted on the oxindole ring displayed the most potent activity with MIC 0.78 ?g/mL and is two-fold active than the standard drug, ethambutol (MIC 1.56 ?g/mL).

Automated summary

Novel spirooxindolopyrrolidine embedded indandione heterocyclic hybrids were synthesized via a one-pot three component reaction with excellent yields. The compounds' structure and stereochemistry were elucidated using spectroscopic data and X-ray diffraction analysis, with the chlorine-substituted compound showing the most potent anti-tubercular activity against Mycobacterium tuberculosis H37Rv.