4.5 Article

1,2,3-Triazole-gold(I)-triethylposphine derivatives active against resistant Gram-positive pathogens

Journal

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 40, Issue -, Pages -

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2021.127879

Keywords

Antibiotic; Gold(I) complex; Azide-alkyne Huisgen cycloaddition; Clostridium difficile; Staphylococcus sp; Enterococcus sp

Funding

  1. Centre National de la Recherche Scientifique (CNRS)

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Innovative organogold(I) antibacterial compounds were synthesized through click chemistry, exhibiting high levels of antibacterial activity against Gram-positive pathogens, with particularly low MICs against Clostridium difficile.
Innovative organogold(I) antibacterial compounds were synthesized by click chemistry with triethylphosphinegold(I) azides and an alkyne derivative. The resulting organo-gold(I) compounds exhibit high levels of antibacterial activity against Gram-positive pathogens, with particularly low MICs against Clostridium difficile.

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