Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 40, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2021.127879
Keywords
Antibiotic; Gold(I) complex; Azide-alkyne Huisgen cycloaddition; Clostridium difficile; Staphylococcus sp; Enterococcus sp
Categories
Funding
- Centre National de la Recherche Scientifique (CNRS)
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Innovative organogold(I) antibacterial compounds were synthesized through click chemistry, exhibiting high levels of antibacterial activity against Gram-positive pathogens, with particularly low MICs against Clostridium difficile.
Innovative organogold(I) antibacterial compounds were synthesized by click chemistry with triethylphosphinegold(I) azides and an alkyne derivative. The resulting organo-gold(I) compounds exhibit high levels of antibacterial activity against Gram-positive pathogens, with particularly low MICs against Clostridium difficile.
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