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A comprehensive review on the biological interest of quinoline and its derivatives

Journal

BIOORGANIC & MEDICINAL CHEMISTRY
Volume 32, Issue -, Pages -

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2020.115973

Keywords

Heterocyclic compounds; Quinolines; Natural sources; Marketed drugs; Approved drugs; Biological Interest

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Quinoline and its derivatives are important compounds with diverse biological activities, making them significant for drug development. Many scientific communities have conducted research on these compounds and evaluated their biological activities and medicinal value.
Amongst heterocyclic compounds, quinoline is an advantaged scaffold that appears as a significant assembly motif for the development of new drug entities. Quinoline and its derivatives tested with diverse biological activity constitute an important class of compounds for new drug development. Therefore, many scientific communities have developed these compounds as intent structure and evaluated their biological activities. The present, review provides brief natural sources of quinoline and including a new extent of quinoline-based marketed drugs. This review also confers information about the biological activities of quinoline derivatives such as antibacterial, antifungal, antimycobacterial, antiviral, anti-protozoal, antimalarial, anticancer, cardiovascular, CNS effects, antioxidant, anticonvulsant, analgesic, anti-inflammatory, anthelmintic and miscellaneous activities.

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