Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 135, Issue -, Pages -Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2020.111189
Keywords
Mycophenolate; Gut dysbiosis; Hypertension; Oxidative stress; Inflammation; SHR
Funding
- Comision Interministerial de Ciencia y Tecnologia, Ministerio de Economia y competitividad [SAF201784894R]
- Junta de Andalucia [CTS-164]
- European Union
- Ministerio de Economia y Competitividad
- Instituto de Salud Carlos III (CIBERCV) , Spain
- European Union (Fondo Europeo de Desarrollo Regional, FEDER, FEDER una manera de hacer Europa)
Ask authors/readers for more resources
The study suggests that MMF reduces gut dysbiosis in SHR by improving gut integrity, reducing neuroinflammation, and enhancing aortic endothelial function, ultimately leading to lower blood pressure in hypertensive rats.
Microbiota has a role in the host blood pressure (BP) regulation. The immunosuppressive drug mofetil myco-phenolate (MMF) ameliorates hypertension. The present study analyzes whether MMF improves dysbiosis in a genetic model of hypertension. Twenty weeks old male spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY) were randomly divided into three groups: untreated WKY, untreated SHR, and SHR treated with MMF for 5 weeks. MMF treatment restored gut bacteria from the phyla Firmicutes and Bacteroidetes, and acetate-and lactate-producing bacteria to levels similar to those found in WKY, increasing butyrate-producing bacteria. MMF increased the percentage of anaerobic bacteria in the gut. The improvement of gut dysbiosis was associated with an enhanced colonic integrity and a decreased sympathetic drive in the gut. MMF inhibited neuroinflammation in the paraventricular nuclei in the hypothalamus. MMF increased the lower regulatory T cells proportion in mesenteric lymph nodes and Th17 and Th1 infiltration in aorta, improved aortic endothelial function and reduced systolic BP. This study demonstrates for the first time that MMF reduces gut dysbiosis in SHR. This effect could be related to its capability to improve gut integrity due to reduced sympathetic drive in the gut associated to the reduced brain neuroinflammation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available