Journal
ELECTROPHORESIS
Volume 37, Issue 10, Pages 1345-1352Publisher
WILEY-BLACKWELL
DOI: 10.1002/elps.201500543
Keywords
Electrochromatography; Mass spectrometry; Microchip
Funding
- Studienstiftung des deutschen Volkes
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In this study, we present the coupling of chip-based electrochromatography to MS using a glass chip with a monolithically integrated nanoelectrospray emitter. As separation column, an acrylate-based porous polymer monolith is implemented into the glass chip by photopolymerization. For the establishment and development of this method, we used a test mixture detectable with both fluorescence and ESI-MS. After successful evaluation of the approach with the test solutes, it was applied exemplarily for drug analysis such as high-speed separations of benzodiazepines in pharmaceuticals.
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