Platinum and zinc oxide modified carbon nitride electrode as non-enzymatic highly selective and reusable electrochemical diabetic sensor in human blood

Development of non-enzymatic glucose sensor is essential to reduce the cost of diabetes regular monitoring. Here, graphitic carbon nitride (g-C3N4) is modified with platinum and zinc oxide for non-enzymatic electrochemical glucose sensing in physiological conditions for the first time in the literature. The interactions between Pt, g-C3N4 and the ZnO are studied using different physicochemical characterization techniques. The Electrochemical glucose sensing at the ZnO-Pt-g-C3N4 occurs at low applied potential of +0.20 V (vs. Ag/AgCl) with high sensitivity 3.34 lA/mM/cm(2) and fast response (5 s) time. This sensor exhibited a wide linear range 0.25-110 mM with lower limit of detection of 0.1 mM. The architectured sensor was evaluated in human blood, serum and urine samples. The sensor is 4 time reusable in whole blood without activity deterioration. This reusable surface helps to reduce the cost of strip. (C) 2020 Elsevier B.V. All rights reserved.

Automated summary

The study introduces a non-enzymatic electrochemical glucose sensor with high sensitivity and fast response time, suitable for monitoring human samples under physiological conditions. The sensor features a wide linear range and low detection limit, and can be reused up to 4 times in whole blood, contributing to cost reduction.