Journal
BIOCHIMIE
Volume 185, Issue -, Pages 9-21Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biochi.2021.03.003
Keywords
Mesenchymal stem cells; Regenerative medicine; Immunomodulation; Tumor; Homing
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Funding
- National Natural Science Foundation of China [81903623]
- China Postdoctoral Science Foundation [2019M652586]
- Postdoctoral Research Grant in Henan Province [19030008, 1902001]
- Henan Medical Science and Technology Program [2018020601]
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Mesenchymal stem cells (MSCs) have immunomodulatory functions and transplantation potential, making them suitable for the treatment of various diseases. They have broad clinical application prospects in tissue regeneration, immunomodulation, and oncology.
Mesenchymal stem cells (MSCs) are multipotent stem cells. In addition to the capacity for self-renewal and multipotential differentiation, MSCs also have the following characteristics. MSCs can exert immu-nomodulatory functions through interaction with innate or adaptive immune cells, MSCs with poor immunogenicity can be used for allogeneic transplantation, and MSCs can home to inflammation and tumour sites. Based on these biological properties, MSCs demonstrate broad clinical application pros-pects in the treatment of tissue injury, autoimmune diseases, transplantation, cancer and other inflammation-related diseases. In this review we describe the biological characteristics of MSCs and discuss the research advances of MSCs in regenerative medicine, immunomodulation, oncology, and COVID-19, to fully understand the range of diseases in which MSC therapy may be beneficial (c) 2021 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Mol & eacute;culaire (SFBBM). All rights reserved.
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