Journal
BIOCHIMIE
Volume 182, Issue -, Pages 13-22Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biochi.2020.12.020
Keywords
FAHFAs; Bioactive lipids; Metabolism; Diabetes; Obesity; Inflammation; Cancer
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Funding
- Algerian Ministry of Higher Education and Scientific Research
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FAHFAs are a new endogenous lipid class with potential to improve glucose tolerance, insulin sensitivity, stimulate insulin secretion, and have anti-inflammatory effects. They could be a potential therapeutic target for treating various metabolic disorders and have generated interest in the field of human health.
Branched Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) are a new endogenous lipid class with recently uncovered interesting biological effects and which have been detected in food of plant and animal origins. Some FAHFAs can improve glucose tolerance and insulin sensitivity, stimulate insulin secretion, and exert anti-inflammatory effects. Other beneficial health effects have also been suggested, in particular against some cancers. FAHFAs could therefore be a potential therapeutic target for the treatment of numerous metabolic disorders such as type II diabetes, hepatic steatosis, cardiovascular diseases and various cancers. Their recent discovery has generated a great interest in the field of human health. This short review aims at bringing together the information available to date in the literature concerning their chemical synthesis, biosynthesis and degradation pathways as well as their potential physio-pathological beneficial effects. (C) 2021 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.
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