Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
Volume 1867, Issue 6, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.bbadis.2021.166122
Keywords
Cerebrospinal fluid; Cytotoxicity; Neuronal cell culture; Synaptic activity; Frontotemporal dementia
Funding
- (European JPND) EU Joint Programme -Neurodegenerative Disease Research program RiMod-FTD Risk and Modifying factors in Fronto Temporal Dementia
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FTD-CSF affects the cortical and spinal cord cultures differently, showing toxic effects on certain types of neurons such as GABA+ and calbindin-D28k+ neurons.
Frontotemporal Lobar Degeneration (FTD) is a neurodegenerative disease characterized by a progressive deterioration of cognitive functions. Currently, no effective treatment exists. We have studied cytotoxicity and neuronal functionality in cortical and spinal cord cultures upon exposure to cerebrospinal fluid (CSF) from 39 FTD patients. FTD-CSF alters the miniature excitatory postsynaptic currents in the cortical cultures and it is toxic to spinal cord cultures, particularly to GABAergic+ and calbindin-D28k + neurons.
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