4.4 Review

The ERK mitogen-activated protein kinase signaling network: the final frontier in RAS signal transduction

Related references

Note: Only part of the references are listed.
Article Oncology

BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition

Marco H. Hofmann et al.

Summary: Inhibiting SOS1, a KRAS activator and important feedback node, is an effective approach to treat KRAS-driven cancers. The highly potent and selective small-molecule SOS1 inhibitor, BI-3406, reduces cellular proliferation of KRAS-driven cancers by preventing the interaction with KRAS. Combination of SOS1 and MEK inhibition represents a novel and effective therapeutic concept for addressing KRAS-driven tumors.

CANCER DISCOVERY (2021)

Article Oncology

Vertical Pathway Inhibition Overcomes Adaptive Feedback Resistance to KRASG12C Inhibition

Meagan B. Ryan et al.

CLINICAL CANCER RESEARCH (2020)

Article Oncology

Cancer statistics, 2020

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

Review Oncology

Germline and sporadic cancers driven by the RAS pathway: parallels and contrasts

V. Dunnett-Kane et al.

ANNALS OF ONCOLOGY (2020)

Article Biochemistry & Molecular Biology

A Live-Cell Screen for Altered Erk Dynamics Reveals Principles of Proliferative Control

Alexander G. Goglia et al.

CELL SYSTEMS (2020)

Review Biotechnology & Applied Microbiology

RAS-targeted therapies: is the undruggable drugged?

Amanda R. Moore et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

Article Multidisciplinary Sciences

Multiple low dose therapy as an effective strategy to treat EGFR inhibitor-resistant NSCLC tumours

Joao M. Fernandes Neto et al.

NATURE COMMUNICATIONS (2020)

Article Chemistry, Medicinal

Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer

Matthew J. LaMarche et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

Article Medicine, Research & Experimental

Ras-Mediated Activation of the Raf Family K nases

Elizabeth M. Terrell et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2019)

Article Oncology

Hyperactivation of MAPK Signaling Is Deleterious to RAS/RAF-mutant Melanoma

Grace P. Leung et al.

MOLECULAR CANCER RESEARCH (2019)

Review Biochemistry & Molecular Biology

Nuclear ERK: Mechanism of Translocation, Substrates, and Role in Cancer

Galia Maik-Rachline et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Biochemistry & Molecular Biology

Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

Kirsten L. Bryant et al.

NATURE MEDICINE (2019)

Article Biochemistry & Molecular Biology

Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers

Conan G. Kinsey et al.

NATURE MEDICINE (2019)

Article Multidisciplinary Sciences

MAP kinase and autophagy pathways cooperate to maintain RAS mutant cancer cell survival

Chih-Shia Lee et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Multidisciplinary Sciences

Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium

Raphael Brandt et al.

NATURE COMMUNICATIONS (2019)

Article Medicine, General & Internal

Encorafenib, Binimetinib, and Cetuximab in BRAF V600E-Mutated Colorectal Cancer

S. Kopetz et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Cell Biology

Development of combination therapies to maximize the impact of KRAS-G12C inhibitors in lung cancer

Miriam Molina-Arcas et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

Article Cell Biology

Drp1 Promotes KRas-Driven Metabolic Changes to Drive Pancreatic Tumor Growth

Sarbajeet Nagdas et al.

CELL REPORTS (2019)

Article Multidisciplinary Sciences

The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity

Jude Canon et al.

NATURE (2019)

Review Endocrinology & Metabolism

Metabolic signatures of cancer cells and stem cells

Andrew M. Intlekofer et al.

NATURE METABOLISM (2019)

Review Chemistry, Multidisciplinary

Genetically Encoded Fluorescent Biosensors Illuminate the Spatiotemporal Regulation of Signaling Networks

Eric C. Greenwald et al.

CHEMICAL REVIEWS (2018)

Review Oncology

Therapeutic strategies to target RAS-mutant cancers

Meagan B. Ryan et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

Article Cell Biology

Fast Dynamic in vivo Monitoring of Erk Activity at Single Cell Resolution in DREKA Zebrafish

Vanessa Mayr et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2018)

Review Biochemistry & Molecular Biology

A compendium of ERK targets

Evrim B. Uenal et al.

FEBS LETTERS (2017)

Article Biochemical Research Methods

Time-resolved Phosphoproteome Analysis of Paradoxical RAF Activation Reveals Novel Targets of ERK

Peter Kubiniok et al.

MOLECULAR & CELLULAR PROTEOMICS (2017)

Article Multidisciplinary Sciences

Cancer drug addiction is relayed by an ERK2-dependent phenotype switch

Xiangjun Kong et al.

NATURE (2017)

Article Biochemistry & Molecular Biology

An approach to suppress the evolution of resistance in BRAFV600E-mutant cancer

Yaohua Xue et al.

NATURE MEDICINE (2017)

Article Biochemistry & Molecular Biology

Linear Integration of ERK Activity Predominates over Persistence Detection in Fra-1 Regulation

Taryn E. Gillies et al.

CELL SYSTEMS (2017)

Article Biochemistry & Molecular Biology

Oncogene-induced senescence underlies the mutual exclusive nature of oncogenic KRAS and BRAF

J. Cisowski et al.

ONCOGENE (2016)

Review Cell Biology

The Emerging Hallmarks of Cancer Metabolism

Natalya N. Pavlova et al.

CELL METABOLISM (2016)

Review Biochemistry & Molecular Biology

Negative feedback regulation of the ERK1/2 MAPK pathway

David Lake et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2016)

Review Cell Biology

The dynamic subcellular localization of ERK: mechanisms of translocation and role in various organelles

Ehud Wainstein et al.

CURRENT OPINION IN CELL BIOLOGY (2016)

Article Biochemical Research Methods

Phosphoproteome analysis of the MAPK pathway reveals previously undetected feedback mechanisms

Florian Gnad et al.

PROTEOMICS (2016)

Article Multidisciplinary Sciences

Opposing effects of Elk-1 multisite phosphorylation shape its response to ERK activation

Anastasia Mylona et al.

SCIENCE (2016)

Article Multidisciplinary Sciences

Allele-specific inhibitors inactivate mutant KRAS G12C by a trapping mechanism

Piro Lito et al.

SCIENCE (2016)

Review Cell Biology

ERK1 and ERK2 Map Kinases: Specific Roles or Functional Redundancy?

Roser Busca et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2016)

Review Neurosciences

Mammalian Target of Rapamycin: Its Role in Early Neural Development and in Adult and Aged Brain Function

Carla Garza-Lombo et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2016)

Article Biochemical Research Methods

A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells

Scott A. Stuart et al.

MOLECULAR & CELLULAR PROTEOMICS (2015)

Article Biochemistry & Molecular Biology

Combination of pan-RAF and MEK inhibitors in NRAS mutant melanoma

Mohammad Atefi et al.

MOLECULAR CANCER (2015)

Article Biochemistry & Molecular Biology

Mitochondrial Division Is Requisite to RAS-Induced Transformation and Targeted by Oncogenic MAPK Pathway Inhibitors

Madhavika N. Serasinghe et al.

MOLECULAR CELL (2015)

Article Medicine, General & Internal

Improved Overall Survival in Melanoma with Combined Dabrafenib and Trametinib

Caroline Robert et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Biochemistry & Molecular Biology

ERK reinforces actin polymerization to power persistent edge protrusion during motility

Michelle C. Mendoza et al.

SCIENCE SIGNALING (2015)

Article Multidisciplinary Sciences

The nuclear translocation of ERK1/2 as an anticancer target

Alexander Plotnikov et al.

NATURE COMMUNICATIONS (2015)

Article Biochemistry & Molecular Biology

ERK reinforces actin polymerization to power persistent edge protrusion during motility

Michelle C. Mendoza et al.

SCIENCE SIGNALING (2015)

Article Oncology

Combined MEK and PI3K Inhibition in a Mouse Model of Pancreatic Cancer

Brinda Alagesan et al.

CLINICAL CANCER RESEARCH (2015)

Article Oncology

Antitumor Activity in RAS-Driven Tumors by Blocking AKT and MEK

Anthony W. Tolcher et al.

CLINICAL CANCER RESEARCH (2015)

Article Oncology

Modeling Targeted Inhibition of MEK and PI3 Kinase in Human Pancreatic Cancer

Melissa R. Junttila et al.

MOLECULAR CANCER THERAPEUTICS (2015)

Article Multidisciplinary Sciences

Novel Reporter for Faithful Monitoring of ERK2 Dynamics in Living Cells and Model Organisms

Francois Sipieter et al.

PLOS ONE (2015)

Review Oncology

Targeting RAS-mutant Cancers: Is ERK the Key?

Meagan B. Ryan et al.

TRENDS IN CANCER (2015)

Article Biochemistry & Molecular Biology

High-Sensitivity Measurements of Multiple Kinase Activities in Live Single Cells

Sergi Regot et al.

Review Biotechnology & Applied Microbiology

Drugging the undruggable RAS: Mission Possible?

Adrienne D. Cox et al.

NATURE REVIEWS DRUG DISCOVERY (2014)

Article Medicine, General & Internal

Combined BRAF and MEK Inhibition versus BRAF Inhibition Alone in Melanoma

G. V. Long et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Medicine, General & Internal

Combined Vemurafenib and Cobimetinib in BRAF-Mutated Melanoma

James Larkin et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Cell Biology

RAF Suppression Synergizes with MEK Inhibition in KRAS Mutant Cancer Cells

Simona Lamba et al.

CELL REPORTS (2014)

Article Biochemistry & Molecular Biology

Frequency-Modulated Pulses of ERK Activity Transmit Quantitative Proliferation Signals

John G. Albeck et al.

MOLECULAR CELL (2013)

Article Biochemistry & Molecular Biology

Phosphoproteome dynamics reveal novel ERK1/2 MAP kinase substrates with broad spectrum of functions

Mathieu Courcelles et al.

MOLECULAR SYSTEMS BIOLOGY (2013)

Article Multidisciplinary Sciences

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

Cosimo Commisso et al.

NATURE (2013)

Article Multidisciplinary Sciences

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

Jaekyoung Son et al.

NATURE (2013)

Article Multidisciplinary Sciences

Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance

Meghna Das Thakur et al.

NATURE (2013)

Article Biochemistry & Molecular Biology

A Versatile Toolkit to Produce Sensitive FRET Biosensors to Visualize Signaling in Time and Space

Rafael D. Fritz et al.

SCIENCE SIGNALING (2013)

Review Oncology

A Comprehensive Survey of Ras Mutations in Cancer

Ian A. Prior et al.

CANCER RESEARCH (2012)

Article Biochemistry & Molecular Biology

A Two-Dimensional ERK-AKT Signaling Code for an NGF-Triggered Cell-Fate Decision

Jia-Yun Chen et al.

MOLECULAR CELL (2012)

Article Medicine, General & Internal

Combined BRAF and MEK Inhibition in Melanoma with BRAF V600 Mutations

Keith T. Flaherty et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Article Medicine, General & Internal

RAS Mutations in Cutaneous Squamous-Cell Carcinomas in Patients Treated with BRAF Inhibitors

Fei Su et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Review Pharmacology & Pharmacy

ERK1/2 MAP kinases: Structure, function, and regulation

Robert Roskoski

PHARMACOLOGICAL RESEARCH (2012)

Article Cell Biology

Pancreatic cancers require autophagy for tumor growth

Shenghong Yang et al.

GENES & DEVELOPMENT (2011)

Article Cell Biology

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

Jessie Yanxiang Guo et al.

GENES & DEVELOPMENT (2011)

Article Cell Biology

Development of an optimized backbone of FRET biosensors for kinases and GTPases

Naoki Komatsu et al.

MOLECULAR BIOLOGY OF THE CELL (2011)

Article Biochemistry & Molecular Biology

ERK-MAPK Drives Lamellipodia Protrusion by Activating the WAVE2 Regulatory Complex

Michelle C. Mendoza et al.

MOLECULAR CELL (2011)

Review Microbiology

Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

Marie Cargnello et al.

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2011)

Article Biochemistry & Molecular Biology

Large-Scale Discovery of ERK2 Substrates Identifies ERK-Mediated Transcriptional Regulation by ETV3

Scott M. Carlson et al.

SCIENCE SIGNALING (2011)

Article Biochemistry & Molecular Biology

Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF

Sonja J. Heidorn et al.

Article Multidisciplinary Sciences

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

Poulikos I. Poulikakos et al.

NATURE (2010)

Article Multidisciplinary Sciences

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

Georgia Hatzivassiliou et al.

NATURE (2010)

Article Biotechnology & Applied Microbiology

Gene ontology analysis for RNA-seq: accounting for selection bias

Matthew D. Young et al.

GENOME BIOLOGY (2010)

Article Biochemical Research Methods

Global Effects of Kinase Inhibitors on Signaling Networks Revealed by Quantitative Phosphoproteomics

Cuiping Pan et al.

MOLECULAR & CELLULAR PROTEOMICS (2009)

Article Biochemistry & Molecular Biology

Functional Proteomics Identifies Targets of Phosphorylation by B-Raf Signaling in Melanoma

William M. Old et al.

MOLECULAR CELL (2009)

Article Biochemistry & Molecular Biology

Rapid and sustained nuclear-cytoplasmic ERK oscillations induced by epidermal growth factor

Harish Shankaran et al.

MOLECULAR SYSTEMS BIOLOGY (2009)

Article Cell Biology

Cell fate decisions are specified by the dynamic ERK interactome

Alex von Kriegsheim et al.

NATURE CELL BIOLOGY (2009)

Article Biochemistry & Molecular Biology

Phosphoproteomics reveals new ERK MAP kinase targets and links ERK to nucleoporin-mediated nuclear transport

Hidetaka Kosako et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)

Review Multidisciplinary Sciences

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Matthew G. Vander Heiden et al.

SCIENCE (2009)

Article Oncology

Genetic Predictors of MEK Dependence in Non-Small Cell Lung Cancer

Christine A. Pratilas et al.

CANCER RESEARCH (2008)

Article Oncology

Active Ras triggers death in glioblastoma cells through hyperstimulation of macropinocytosis

Jean H. Overmeyer et al.

MOLECULAR CANCER RESEARCH (2008)

Article Multidisciplinary Sciences

Modelling Myc inhibition as a cancer therapy

Laura Soucek et al.

NATURE (2008)

Article Cell Biology

Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate

Silvia D. M. Santos et al.

NATURE CELL BIOLOGY (2007)

Article Cell Biology

ERK1c regulates Golgi fragmentation during mitosis

YD Shaul et al.

JOURNAL OF CELL BIOLOGY (2006)

Article Biochemistry & Molecular Biology

Docking motif interactions in MAP kinases revealed by hydrogen exchange mass spectrometry

T Lee et al.

MOLECULAR CELL (2004)

Review Cell Biology

Upstream and downstream of mTOR

N Hay et al.

GENES & DEVELOPMENT (2004)

Article Cell Biology

Sef is a spatial regulator for Ras/MAP kinase signaling

S Torii et al.

DEVELOPMENTAL CELL (2004)

Review Cell Biology

Ras pathway signaling on endomembranes

TG Bivona et al.

CURRENT OPINION IN CELL BIOLOGY (2003)

Article Biochemistry & Molecular Biology

Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D

M Schmidt et al.

MOLECULAR AND CELLULAR BIOLOGY (2002)

Article Biochemistry & Molecular Biology

Docking sites on substrate proteins direct extracellular signal-regulated kinase to phosphorylate specific residues

DA Fantz et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)