Journal
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
Volume 75, Issue -, Pages 37-53Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.bpobgyn.2021.01.013
Keywords
Ovarian transposition; Cervical cancer; Fertility preservation; Ovarian function; Pelvic radiotherapy
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Cervical cancer is the fourth most common female malignancy worldwide, and ovarian transposition remains a safe option for preserving ovarian function, but its usage is controversial due to the scarcity of data and clinical trials.
Cervical cancer is the fourth most common female malignancy worldwide. As the focus of treatment is shifting towards balancing oncological outcomes with reproductive benefit, women are becoming increasingly aware of their fertility options. Cervical cancer is one of the primary malignancies where transposition of the ovaries may be indicated. Ovarian transposition should be performed in pre-menopausal women, undergoing pelvic irradiation to preserve ovarian function and prevent early menopause. The review discusses the available literature and synthesises a concise summary for gynaecologic oncology surgeons to counsel affected women. The paradoxical controversy, leading to its under use is acknowledged, due to the scarcity of published data with regard to functional outcomes, and the lack of clinical trials. In cervical cancer, ovarian transposition remains a safe fertility preservation (FP) option, which is associated with high ovarian function preservation, an acceptable rate of ovarian cysts and a negligible risk for metastases in the transposed ovaries. (c) 2021 Published by Elsevier Ltd.
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