Journal
AUTOIMMUNITY REVIEWS
Volume 20, Issue 2, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.autrev.2020.102738
Keywords
Precision medicine; rheumatoid arthritis; spondyloarthritides; systemic lupus erythematosus; antiphospholipid syndrome; primary Sjogren's syndrome; systemic sclerosis
Categories
Funding
- MRC [G0800648, MR/N003063/1, MR/K015346/1] Funding Source: UKRI
Ask authors/readers for more resources
Autoimmune diseases share common clinical features but have different pathogenic mechanisms and targeted organs. Applying precision medicine principles may improve treatment success by tailoring therapy to individual characteristics and reducing adverse events.
Autoimmune diseases (AIDs) share similar serological, clinical, and radiological findings, but, behind these common features, there are different pathogenic mechanisms, immune cells dysfunctions, and targeted organs. In this context, multiple lines of evidence suggest the application of precision medicine principles to AIDs to reduce the treatment failure. Precision medicine refers to the tailoring of therapeutic strategies to the individual characteristics of each patient, thus it could be a new approach for management of AIDS which considers individual variability in genes, environmental exposure, and lifestyle. Precision medicine would also assist physicians in choosing the right treatment, the best timing of administration, consequently trying to maximize drug efficacy, and, possibly, reducing adverse events. In this work, the growing body of evidence is summarized regarding the predictive factors for drug response in patients with AIDs, applying the precision medicine principles to provide high-quality evidence for therapeutic opportunities in improving the management of these patients.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available