Journal
ARCHIVES OF VIROLOGY
Volume 166, Issue 4, Pages 1259-1262Publisher
SPRINGER WIEN
DOI: 10.1007/s00705-021-04990-7
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Funding
- Program for the National Key Research and Development Program of China [2018YFD0501800]
- Sichuan Science and Technology Program [2018NZ0002/2019YFQ0012]
- Sichuan Beef Cattle Innovation Team of National Modern Agricultural Industry Technology System [035Z2036]
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In 2019, diarrhea cases were reported on cattle farms in Qionglai and Guang'an, Sichuan Province. Two non-cytopathic strains of BVDV were isolated, with different genetic subtypes identified.
In 2019, diarrhea cases occurred on cattle farms in Qionglai and Guang'an, Sichuan Province. Two out of 20 (10%) serum and nasal swab samples were positive when tested using a bovine viral diarrhea virus (BVDV) antigen-capture ELISA kit. Two non-cytopathic strains of BVDV were isolated and named QL1903 and GA190608, respectively. The nucleotide sequences of the genomes of the two isolates were 89.52% identical. Phylogenetic analysis based on the 5'-UTR sequence revealed that the BVDV isolate QL1903 belonged to BVDV subtype 1b, whereas isolate GA190608 clustered with strains HN1814, EN-19, and BJ09_26 in a separate branch, which has tentatively been classified as a new genetic subtype, 1v.
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