Related references
Note: Only part of the references are listed.Accessing Enantiopure Epoxides and Sulfoxides: Related Flavin-Dependent Monooxygenases Provide Reversed Enantioselectivity
Thomas Heine et al.
CHEMCATCHEM (2020)
MymA Bioactivated Thioalkylbenzoxazole Prodrug Family Active against Mycobacterium tuberculosis
Abraham L. Moure et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
Trapping conformational states of a flavin-dependentN-monooxygenasein crystalloreveals protein and flavin dynamics
Ashley C. Campbell et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2020)
Structural Determinants of Flavin Dynamics in a Class B Monooxygenase
Ashley C. Campbell et al.
BIOCHEMISTRY (2020)
Flavin oxidation in flavin-dependent N-monooxygenases
Reeder M. Robinson et al.
PROTEIN SCIENCE (2019)
Aspergillus flavus squalene synthase as an antifungal target: Expression, activity, and inhibition
Junfeng Song et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)
The shape of human squalene epoxidase expands the arsenal against cancer
Andrew J. Brown et al.
NATURE COMMUNICATIONS (2019)
Emergence of plasmid-mediated high-level tigecycline resistance genes in animals and humans
Tao He et al.
NATURE MICROBIOLOGY (2019)
A novel sulfonamide resistance mechanism by two-component flavin-dependent monooxygenase system in sulfonamide-degrading actinobacteria
Dae-Wi Kim et al.
ENVIRONMENT INTERNATIONAL (2019)
Hydroxyl Radical-Coupled Electron-Transfer Mechanism of Flavin-Dependent Hydroxylases
Sara E. Tweedy et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2019)
Identifying the Biosynthetic Gene Cluster for Triacsins with an N-Hydroxytriazene Moiety
Frederick F. Twigg et al.
CHEMBIOCHEM (2019)
Beyond active site residues: overall structural dynamics control catalysis in flavin-containing and heme-containing monooxygenases
Maximilian J. L. J. Furst et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2019)
Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase
Anil K. Padyana et al.
NATURE COMMUNICATIONS (2019)
A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition
Christopher E. Mahoney et al.
NATURE COMMUNICATIONS (2019)
Modulation of Enzyme Activity in the Kynurenine Pathway by Kynurenine Monooxygenase Inhibition
Robert S. Phillips et al.
FRONTIERS IN MOLECULAR BIOSCIENCES (2019)
A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites
Shaowei Zhang et al.
COMMUNICATIONS BIOLOGY (2019)
Structural Evidence for Rifampicin Monooxygenase Inactivating Rifampicin by Cleaving Its Ansa-Bridge
Li-Kai Liu et al.
BIOCHEMISTRY (2018)
Same Substrate, Many Reactions: Oxygen Activation in Flavoenzymes
Elvira Romero et al.
CHEMICAL REVIEWS (2018)
PcxL and HpxL are flavin-dependent, oxime-forming N-oxidases in phosphonocystoximic acid biosynthesis in Streptomyces
Michelle N. Goettge et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2018)
Development of a Rapid Fluorescence-Based High-Throughput Screening Assay to Identify Novel Kynurenine 3-Monooxygenase Inhibitor Scaffolds
K. R. Jacobs et al.
SLAS DISCOVERY (2018)
撤稿声明: Crystal structure of a Baeyer-Villiger flavin-containing monooxygenase from Staphylococcus aureus MRSA strain MU50 (Retraction of 2014)
William C. Hwang et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2018)
Characterization of MymA protein as a flavin-containing monooxygenase and as a target of isoniazid
Iti Saraav et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2017)
Plasticity, dynamics, and inhibition of emerging tetracycline resistance enzymes
Jooyoung Park et al.
NATURE CHEMICAL BIOLOGY (2017)
Flavins as Covalent Catalysts: New Mechanisms Emerge
Valentina Piano et al.
TRENDS IN BIOCHEMICAL SCIENCES (2017)
Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase
Jonathan P. Hutchinson et al.
NATURE COMMUNICATIONS (2017)
FMNH2-dependent monooxygenases initiate catabolism of sulfonamides in Microbacterium sp strain BR1 subsisting on sulfonamide antibiotics
Benjamin Ricken et al.
SCIENTIFIC REPORTS (2017)
Flavin-catalyzed redox tailoring reactions in natural product biosynthesis
Robin Teufel
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2017)
Inhibition of the Flavin-Dependent Monooxygenase Siderophore A (SidA) Blocks Siderophore Biosynthesis and Aspergillus fumigatus Growth
Julia S. Martin del Campo et al.
ACS CHEMICAL BIOLOGY (2016)
Characterization of a new Baeyer-Villiger monooxygenase and conversion to a solely N-or S-oxidizing enzyme by a single R292 mutation
Gianluca Catucci et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2016)
Sweating the assets of flavin cofactors: new insight of chemical versatility from knowledge of structure and mechanism
David Leys et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2016)
Kynurenine-3-monooxygenase: a review of structure, mechanism, and inhibitors
Jason R. Smith et al.
DRUG DISCOVERY TODAY (2016)
The Structure of the Antibiotic Deactivating, N-hydroxylating Rifampicin Monooxygenase
Li-Kai Liu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Chopping and Changing: the Evolution of the Flavin-dependent Monooxygenases
Maria Laura Mascotti et al.
JOURNAL OF MOLECULAR BIOLOGY (2016)
A Flavin-Dependent Decarboxylase Dehydrogenase Monooxygenase Assembles the Warhead of α,β-Epoxyketone Proteasome Inhibitors
Daniel Zabala et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)
OxaD: A Versatile Indolic Nitrone Synthase from the Marine-Derived Fungus Penicillium oxalicum F30
Sean A. Newmister et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)
Phenalenone Polyketide Cyclization Catalyzed by Fungal Polyketide Synthase and Flavin-Dependent Monooxygenase
Shu-Shan Gao et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)
Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis
Damian J. Mole et al.
NATURE MEDICINE (2016)
New insights into the biosynthesis of fosfazinomycin
Zedu Huang et al.
CHEMICAL SCIENCE (2016)
An Unprecedented NADPH Domain Conformation in Lysine Monooxygenase NbtG Provides Insights into Uncoupling of Oxygen Consumption from Substrate Hydroxylation
Claudia Binda et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Mechanism of N-Hydroxylation Catalyzed by Flavin-Dependent Monooxygenases
Somayesadat Badieyan et al.
JOURNAL OF ORGANIC CHEMISTRY (2015)
Genetic Basis for the Biosynthesis of the Pharmaceutically Important Class of Epoxyketone Proteasome Inhibitors
Michelle Schorn et al.
ACS CHEMICAL BIOLOGY (2014)
Mechanistic studies on the flavin-dependent N6-lysine monooxygenase MbsG reveal an unusual control for catalysis
Reeder M. Robinson et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2014)
Flavin dependent monooxygenases
Mieke M. E. Huijbers et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2014)
Control of C4a-Hydroperoxyflavin Protonation in the Oxygenase Component of p-Hydroxyphenylacetate-3-hydroxylase
Pirom Chenprakhon et al.
BIOCHEMISTRY (2014)
Crystallographic Evidence of Drastic Conformational Changes in the Active Site of a Flavin-Dependent N-Hydroxylase
Jeremy W. Setser et al.
BIOCHEMISTRY (2014)
Proton-Coupled Electron Transfer and Adduct Configuration Are Important for C4a-Hydroperoxyflavin Formation and Stabilization in a Flavoenzymed
Thanyaporn Wongnate et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)
C4a-Hydroperoxyflavin Formation in N-Hydroxylating Flavin Monooxygenases Is Mediated by the 2′-OH of the Nicotinamide Ribose of NADP+
Reeder Robinson et al.
BIOCHEMISTRY (2013)
Role of Ser-257 in the Sliding Mechanism of NADP(H) in the Reaction Catalyzed by the Aspergillus fumigatus Flavin-dependent Ornithine N5-Monooxygenase SidA
Carolyn Shirey et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Mechanistic Aspects Regarding the Elimination of H2O2 from C(4a)-Hydroperoxyflavin. The Role of a Proton Shuttle Required for H2O2 Elimination
Robert D. Bach et al.
JOURNAL OF ORGANIC CHEMISTRY (2013)
Insights into Caerulomycin A Biosynthesis: A Two-Component Monooxygenase CrmH-Catalyzed Oxime Formation
Yiguang Zhu et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)
Uncovering the Enzymes that Catalyze the Final Steps in Oxytetracycline Biosynthesis
Peng Wang et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)
Flavoenzymes: Versatile catalysts in biosynthetic pathways
Christopher T. Walsh et al.
NATURAL PRODUCT REPORTS (2013)
Structural Insight into the Mechanism of Oxygen Activation and Substrate Selectivity of Flavin-Dependent N-Hydroxylating Monooxygenases
Stefano Franceschini et al.
BIOCHEMISTRY (2012)
Form Follows Function: Structural and Catalytic Variation in the Class A Flavoprotein Monooxygenases
Karen Crozier-Reabe et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2012)
Fungal Origins of the Bicyclo[2.2.2]diazaoctane Ring System of Prenylated Indole Alkaloids
Jennifer M. Finefield et al.
JOURNAL OF NATURAL PRODUCTS (2012)
Theoretical Study of the Mechanism of the Hydride Transfer between Ferredoxin-NADP+ Reductase and NADP+: The Role of Tyr303
Isaias Lans et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
The enigmatic reaction of flavins with oxygen
Pimchai Chaiyen et al.
TRENDS IN BIOCHEMICAL SCIENCES (2012)
Structural basis for a new tetracycline resistance mechanism relying on the TetX monooxygenase
Gesa Volkers et al.
FEBS LETTERS (2011)
Interactions with the Substrate Phenolic Group Are Essential for Hydroxylation by the Oxygenase Component of p-Hydroxyphenylacetate 3-Hydroxylase
Chanakan Tongsook et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Snapshots of Enzymatic Baeyer-Villiger Catalysis OXYGEN ACTIVATION AND INTERMEDIATE STABILIZATION
Roberto Orru et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Stabilization of C4a-Hydroperoxyflavin in a Two-component Flavin-dependent Monooxygenase Is Achieved through Interactions at Flavin N5 and C4a Atoms
Kittisak Thotsaporn et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Role of the Somersault Rearrangement in the Oxidation Step for Flavin Monooxygenases (FMO). A Comparison between FMO and Conventional Xenobiotic Oxidation with Hydroperoxides
Robert D. Bach
JOURNAL OF PHYSICAL CHEMISTRY A (2011)
Crystal structure of Bacteroides thetaiotaomicron TetX2: A tetracycline degrading monooxygenase at 2.8 Å resolution
Katarzyna Walkiewicz et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2011)
Control of catalysis in flavin-dependent monooxygenases
Bruce A. Palfey et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2010)
Monooxygenation of rifampicin catalyzed by the rox gene product of Nocardia farcinica: structure elucidation, gene identification and role in drug resistance
Yasutaka Hoshino et al.
JOURNAL OF ANTIBIOTICS (2010)
Prenylated indole derivatives from fungi: structure diversity, biological activities, biosynthesis and chemoenzymatic synthesis
Shu-Ming Li
NATURAL PRODUCT REPORTS (2010)
Crystal Structures of Cyclohexanone Monooxygenase Reveal Complex Domain Movements and a Sliding Cofactor
I. Ahmad Mirza et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
Kynurenine 3-Monooxygenase from Pseudomonas fluorescens: Substrate-like Inhibitors both Stimulate Flavin Reduction and Stabilize the Flavin-Peroxo Intermediate yet Result in the Production of Hydrogen Peroxide
Karen R. Crozier-Reabe et al.
BIOCHEMISTRY (2008)
Revealing the moonlighting role of NADP in the structure of a flavin-containing monooxygenase
Andrea Alfieri et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Biochemical characterization of a flavin adenine dinculeotide-dependent monooxygenase, ornithine hydroxylase from Pseudomonas aeruginosa, suggests a novel reaction mechanism
Kathleen M. Meneely et al.
BIOCHEMISTRY (2007)
Cloning and characterization of the biosynthetic gene cluster for kutznerides
Danica Galonic Fujimori et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Insights into the mechanisms of flavoprotein oxidases from kinetic isotope effects
Paul F. Fitzpatrick
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS (2007)
Time-resolved fluorescence analysis of the mobile flavin cofactor in p-hydroxybenzoate hydroxylase
Petra A. W. Van Den Berg et al.
JOURNAL OF CHEMICAL SCIENCES (2007)
Novel acetone metabolism in a propane-utilizing bacterium, Gordonia sp strain TY-5
Tetsuya Kotani et al.
JOURNAL OF BACTERIOLOGY (2007)
New frontiers in structural flavoenzymology
Luigi De Colibus et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2006)
Flavoprotein monooxygenases, a diverse class of oxidative biocatalysts
W. J. H. van Berkel et al.
JOURNAL OF BIOTECHNOLOGY (2006)
Mechanism of action of a flavin-containing monooxygenase
Subramaniam Eswaramoorthy et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Characterization of kinetics and products of the Baeyer-Villiger oxygenase MtmOIV, the key enzyme of the biosynthetic pathway toward the natural product anticancer drug mithramycin from Streptomyces argillaceus
M Gibson et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
Enzymatic hydroxylation in p-hydroxybenzoate hydroxylase:: A case study for QM/MM molecular dynamics
HM Senn et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2005)
Protein dynamics and electrostatics in the function of p-hydroxybenzoate hydroxylase
B Entsch et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2005)
Crystal structure of a Baeyer-Villiger monooxygenase
E Malito et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Trypanocidal effect of α′,β′-epoxyketones indicates that trypanosomes are particularly sensitive to inhibitors of proteasome trypsin-like activity
RJ Glenn et al.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2004)
Open questions in ferredoxin-NADP+ reductase catalytic mechanism
N Carrillo et al.
EUROPEAN JOURNAL OF BIOCHEMISTRY (2003)
Ab initio QM/MM modeling of the hydroxylation step in p-hydroxybenzoate hydroxylase
L Ridder et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2003)
Role of protein flexibility in the catalytic cycle of p-hydroxybenzoate hydroxylase elucidated by the Pro293Ser mutant
BA Palfey et al.
BIOCHEMISTRY (2002)
Electrostatics of nanosystems: Application to microtubules and the ribosome
NA Baker et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Share Paper
