Multidrug-Resistant Plasmodium falciparum Parasites in the Central Highlands of Vietnam Jeopardize Malaria Control and Elimination Strategies

Plasmodium falciparum resistance to dihydroartemisinin-piperaquine has spread through the Greater Mekong Subregion to southwestern Vietnam. In 2018 to 2019, we collected 127 P. falciparum isolates from Dak Nong (36), Dak Lak (55), Gia Lai (13), and Kon Tum (23) provinces in Vietnam's Central Highlands and found parasites bearing the Pfkelch13 C580Y mutation and multiple plasmepsin 2/3 genes (mean prevalence, 17.9%; range, 4.3% to 27.8%), conferring resistance to dihydroartemisinin-piperaquine. This information is important for drug policy decisions in Vietnam.

Automated summary

Resistance to dihydroartemisinin-piperaquine has spread to southwestern Vietnam through the Greater Mekong Subregion. The presence of mutations in Pfkelch13 C580Y and multiple plasmepsin 2/3 genes in P. falciparum isolates collected from the Central Highlands highlights the urgency of drug policy decisions in Vietnam.