Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 65, Issue 4, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.02167-20
Keywords
antimicrobial stewardship; COVID-19; procalcitonin
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Funding
- National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH) [5UM1AI069470-14, K23AI150378, L30AI133789]
- NIH NIAID [T32AI114398]
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The role of procalcitonin in identifying community-associated bacterial infections among patients with coronavirus disease 2019 is not yet established. Procalcitonin did not reliably identify bacterial coinfections, but may be useful in excluding bacterial infection.
The role of procalcitonin in identifying community-associated bacterial infections among patients with coronavirus disease 2019 is not yet established. In 2,443 patients of whom 148 had bacterial coinfections, mean procalcitonin levels were significantly higher with any bacterial infection (13.16 +/- 51.19 ng/ml; P = 0.0091) and with bacteremia (34.25 +/- 85.01 ng/ml; P = 0.0125) than without infection (2.00 +/- 15.26 ng/ml). Procalcitonin (cutoff, 0.25 or 0.50 ng/ml) did not reliably identify bacterial coinfections but may be useful in excluding bacterial infection.
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