Related references
Note: Only part of the references are listed.A Kelch13-defined endocytosis pathway mediates artemisinin resistance in malaria parasites
Jakob Birnbaum et al.
SCIENCE (2020)
The Plasmodium falciparum Artemisinin Susceptibility-Associated AP-2 Adaptin μ Subunit is Clathrin Independent and Essential for Schizont Maturation
Ryan C. Henrici et al.
MBIO (2020)
Role of Plasmodium falciparum Kelch 13 Protein Mutations in P. falciparum Populations from Northeastern Myanmar in Mediating Artemisinin Resistance
Faiza Amber Siddiqui et al.
MBIO (2020)
Malaria parasite plasmepsins: More than just plain old degradative pepsins
Armiyaw S. Nasamu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2020)
Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13
Nina F. Gnädig et al.
PLoS Pathogens (2020)
K13, the Cytostome, and Artemisinin Resistance
Stanley C. Xie et al.
TRENDS IN PARASITOLOGY (2020)
Genetic screens reveal a central role for heme metabolism in artemisinin susceptibility
Clare R. Harding et al.
NATURE COMMUNICATIONS (2020)
Artesunate activation by heme in an aqueous medium
Laura Heller et al.
INORGANICA CHIMICA ACTA (2019)
Mode of action of quinoline antimalarial drugs in red blood cells infected by Plasmodium falciparum revealed in vivo
Sergey Kapishnikov et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
Antimalarial Quinoline Drugs Inhibit β-Hematin and Increase Free Hemin Catalyzing Peroxidative Reactions and Inhibition of Cysteine Proteases
Tomas Herraiz et al.
SCIENTIFIC REPORTS (2019)
Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance
Tuo Yang et al.
CELL REPORTS (2019)
Stochastic Protein Alkylation by Antimalarial Peroxides
Joelle Jourdan et al.
ACS INFECTIOUS DISEASES (2019)
Ozonide Antimalarials Alkylate Heme in the Malaria Parasite Plasmodium falciparum
Carlo Giannangelo et al.
ACS INFECTIOUS DISEASES (2019)
Origin and Spread of Evolving Artemisinin-Resistant Plasmodium falciparum Malarial Parasites in Southeast Asia
Matthew R. Hassett et al.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2019)
Artemisinin-Based Antimalarial Drug Therapy: Molecular Pharmacology and Evolving Resistance
Laura E. Heller et al.
TROPICAL MEDICINE AND INFECTIOUS DISEASE (2019)
Remodeling of the malaria parasite and host human red cell by vesicle amplification that induces artemisinin resistance
Souvik Bhattacharjee et al.
BLOOD (2018)
Uncovering the essential genes of the human malaria parasite Plasmodium falciparum by saturation mutagenesis
Min Zhang et al.
SCIENCE (2018)
Dihydroartemisinin-Ferriprotoporphyrin IX Adduct Abundance in Plasmodium falciparum Malarial Parasites and the Relationship to Emerging Artemisinin Resistance
Laura E. Heller et al.
BIOCHEMISTRY (2018)
Quantification of Free Ferriprotoporphyrin IX Heme and Hemozoin for Artemisinin Sensitive versus Delayed Clearance Phenotype Plasmodium falciparum Malarial Parasites
Laura E. Heller et al.
BIOCHEMISTRY (2018)
A genetic system to study Plasmodium falciparum protein function
Jakob Birnbaum et al.
NATURE METHODS (2017)
A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile
Hanafy M. Ismail et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)
Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7
Hanafy M. Ismail et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Artemisinin-Resistant Plasmodium falciparum Parasites Exhibit Altered Patterns of Development in Infected Erythrocytes
Amanda Hott et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)
Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum
Jigang Wang et al.
NATURE COMMUNICATIONS (2015)
High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations
Bryan T. Mott et al.
SCIENTIFIC REPORTS (2015)
K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates
Judith Straimer et al.
SCIENCE (2015)
Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases
Alugoju Phaniendra et al.
INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY (2015)
Plasmodium prevalence and artemisinin-resistant falciparum malaria in Preah Vihear Province, Cambodia: a cross-sectional population-based study
Philippe Bosman et al.
MALARIA JOURNAL (2014)
Spread of Artemisinin Resistance in Plasmodium falciparum Malaria
E. A. Ashley et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
To kill or not to kill, that is the question: cytocidal antimalarial drug resistance
Paul D. Roepe
TRENDS IN PARASITOLOGY (2014)
Identification of β-hematin inhibitors in a high-throughput screening effort reveals scaffolds with in vitro antimalarial activity
Rebecca D. Sandlin et al.
INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE (2014)
Cytostatic versus Cytocidal Activities of Chloroquine Analogues and Inhibition of Hemozoin Crystal Growth
Alexander P. Gorka et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2013)
Hemozoin and antimalarial drug discovery
Kim Y. Fong et al.
FUTURE MEDICINAL CHEMISTRY (2013)
Quinoline Drug-Heme Interactions and Implications for Antimalarial Cytostatic versus Cytocidal Activities
Alexander P. Gorka et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Cytostatic versus cytocidal profiling of quinoline drug combinations via modified fixed-ratio isobologram analysis
Alexander P. Gorka et al.
MALARIA JOURNAL (2013)
Phospholipid Membrane-Mediated Hemozoin Formation: The Effects of Physical Properties and Evidence of Membrane Surrounding Hemozoin
Nguyen Tien Huy et al.
PLOS ONE (2013)
A Process Similar to Autophagy Is Associated with Cytocidal Chloroquine Resistance in Plasmodium falciparum
David Gaviria et al.
PLOS ONE (2013)
Iron(III) Protoporphyrin IX Complexes of the Antimalarial Cinchona Alkaloids Quinine and Quinidine
Katherine A. de Villiers et al.
ACS CHEMICAL BIOLOGY (2012)
A simple and inexpensive haemozoin-based colorimetric method to evaluate anti-malarial drug activity
Tran Thanh Men et al.
MALARIA JOURNAL (2012)
Rethinking the term pi-stacking
Chelsea R. Martinez et al.
CHEMICAL SCIENCE (2012)
Proteases in Malaria Parasites - A Phylogenomic Perspective
Hong Cai et al.
CURRENT GENOMICS (2011)
Chemical Biology of Peroxynitrite: Kinetics, Diffusion, and Radicals
Gerardo Ferrer-Sueta et al.
ACS CHEMICAL BIOLOGY (2009)
Artemisinin Resistance in Plasmodium falciparum Malaria.
Arjen M. Dondorp et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Unravelling the intrinsic features of NO binding to iron(II)- and iron(III)-hemes
Barbara Chiavarino et al.
INORGANIC CHEMISTRY (2008)
The crystal structure of halofantrine-ferriprotoporphyrin IX and the mechanism of action of arylmethanol antimalarials
Katherine A. de Villiers et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2008)
Evidence of Artemisinin-Resistant Malaria in Western Cambodia
Harald Noedl et al.
NEW ENGLAND JOURNAL OF MEDICINE (2008)
Ferric and ferrous iron in nitroso-myoglobin: Computer simulations of stable and metastable states and their infrared spectra
David R. Nutt et al.
CHEMPHYSCHEM (2007)
The role of neutral lipid nanospheres in Plasmodium falciparum haem crystallization
John M. Pisciotta et al.
BIOCHEMICAL JOURNAL (2007)
Simple colorimetric inhibition assay of heme crystallization for high-throughput screening of antimalarial compounds
Nguyen Tien Huy et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2007)
Spinning disk confocal microscopy of live, intraerythrocytic malarial parasites. 1. Quantification of hemozoin development for drug sensitive versus resistant malaria
Bojana Gligorijevic et al.
BIOCHEMISTRY (2006)
Spinning disk confocal microscopy of live, intraerythrocytic malarial parasites. 2. Altered vacuolar volume regulation in drug resistant malaria
Bojana Gligorijevic et al.
BIOCHEMISTRY (2006)
Inhibition assay of β-hematin formation initiated by lecithin for screening new antimalarial drugs
DTX Trang et al.
ANALYTICAL BIOCHEMISTRY (2006)
The antimalarial drug artemisinin alkylates heme in infected mice
A Robert et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Dispiro-1,2,4-trioxane analogues of a prototype dispiro-1,2,4-trioxolane: Mechanistic comparators for artemisinin in the context of reaction pathways with iron(II)
YQ Tang et al.
JOURNAL OF ORGANIC CHEMISTRY (2005)
A colorimetric high-throughput β-hematin inhibition screening assay for use in the search for antimalarial compounds
KK Ncokazi et al.
ANALYTICAL BIOCHEMISTRY (2005)
Spectrophotometric determination of de novo hemozoin/β-hematin formation in an in vitro assay
AK Tripathi et al.
ANALYTICAL BIOCHEMISTRY (2004)
Oxidative stress in malaria parasite-infected erythrocytes: host-parasite interactions
K Becker et al.
INTERNATIONAL JOURNAL FOR PARASITOLOGY (2004)
Food vacuole-associated lipid bodies and heterogeneous lipid environments in the malaria parasite, Plasmodium falciparum
KE Jackson et al.
MOLECULAR MICROBIOLOGY (2004)
Redox and antioxidant systems of the malaria parasite Plasmodium falciparum
S Müller
MOLECULAR MICROBIOLOGY (2004)
Structure of the amodiaquine-FPIX μ oxo dimer solution complex at atomic resolution
AC de Dios et al.
INORGANIC CHEMISTRY (2004)
Drug resistance-associated pfCRT mutations confer decreased Plasmodium falciparum digestive vacuolar pH
TN Bennett et al.
MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2004)
Inhibition of heme crystal growth by antimalarials and other compounds: implications for drug discovery
CR Chong et al.
BIOCHEMICAL PHARMACOLOGY (2003)
NMR studies of chloroquine-ferriprotoporphyrin IX complex
AC de Dios et al.
JOURNAL OF PHYSICAL CHEMISTRY A (2003)
The determination of the stability constant for the iron(II) complex of the biochelator pyridine-2,6-bis(monothiocarboxylic acid)
MS Brandon et al.
BIODEGRADATION (2003)
Glutathione is involved in the antimalarial action of chloroquine and its modulation affects drug sensitivity of human and murine species of Plasmodium
H Ginsburg et al.
REDOX REPORT (2003)
Oxidation of biological systems: Oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification
A Nyska et al.
TOXICOLOGIC PATHOLOGY (2002)
Solution structures of antimalarial drug-heme complexes
A Leed et al.
BIOCHEMISTRY (2002)
Laser flash photolysis as tool in the elucidation of the nitric oxide binding mechanism to metallobiomolecules
A Wanat et al.
COORDINATION CHEMISTRY REVIEWS (2002)
Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine
R Banerjee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
A physiochemical mechanism of hemozoin (β-hematin) synthesis by malaria parasite
AK Tripathi et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)
Alkylation of heme by the antimalarial drug artemisinin
A Robert et al.
CHEMICAL COMMUNICATIONS (2002)
Hematin polymerization assay as a high-throughput screen for identification of new antimalarial pharmacophores
Y Kurosawa et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2000)