Journal
ANNUAL REVIEW OF PHYSICAL CHEMISTRY, VOL 72
Volume 72, Issue -, Pages 467-488Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-physchem-090519-050109
Keywords
bioelectrocatalysis; enzymatic cascade; organic catalyst; biofuel cell; bioelectrosynthesis; biosensor
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Funding
- US Army Research Office Multidisciplinary University Research Initiative (MURI)
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Enzyme cascades are abundant in nature and have potential in artificial applications. Strategies of cascade biocatalysis and bioelectrocatalysis can address CO2 fixation, high value-added product formation, sustainable energy sources, and sensitive analyte detection through electrochemical enzymatic biosensors.
Enzyme cascades are plentiful in nature, but they also have potential in artificial applications due to the possibility of using the target substrate in biofuel cells, electrosynthesis, and biosensors. Cascade reactions from enzymes or hybrid bioorganic catalyst systems exhibit extended substrate range, reaction depth, and increased overall performance. This review addresses the strategies of cascade biocatalysis and bioelectrocatalysis for (a) CO2 fixation, (b) high value-added product formation, (c) sustainable energy sources via deep oxidation, and (d) cascaded electrochemical enzymatic biosensors. These recent updates in the field provide fundamental concepts, designs of artificial electrocatalytic oxidation-reduction pathways (using a flexible setup involving organic catalysts and engineered enzymes), and advances in hybrid cascaded sensors for sensitive analyte detection.
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