Use of Circulating Cell-Free DNA to Guide Precision Medicine in Patients with Colorectal Cancer

Patient-specific biomarkers form the foundation of precision medicine strategies. To realize the promise of precision medicine in patients with colorectal cancer (CRC), access to cost-effective, convenient, and safe assays is critical. Improvements in diagnostic technology have enabled ultrasensitive and specific assays to identify cell-free DNA (cfDNA) from a routine blood draw. Clinicians are already employing these minimally invasive assays to identify drivers of therapeutic resistance and measure genomic heterogeneity, particularly when tumor tissue is difficult to access or serial sampling is necessary. As cfDNA diagnostic technology continues to improve, more innovative applications are anticipated. In this review, we focus on four clinical applications for cfDNA analysis in the management of CRC: detecting minimal residual disease, monitoring treatment response in the metastatic setting, identifying drivers of treatment sensitivity and resistance, and guiding therapeutic strategies to overcome resistance.

Automated summary

Patient-specific biomarkers are crucial for precision medicine, and in the case of colorectal cancer (CRC), analyzing cfDNA can be used for detecting minimal residual disease, monitoring treatment response, identifying drivers of treatment sensitivity and resistance, and guiding therapeutic strategies. As diagnostic technology continues to improve, more innovative applications of cfDNA analysis are expected.