ASO Author Reflections: Expression and Role of CFTR in Human Esophageal Squamous Cell Carcinoma

Summary: Overexpression of CFTR in ESCC activates the p38 signaling pathway and is associated with a good patient prognosis. CFTR shows potential as a mediator and/or a biomarker for ESCC. Immunohistochemical analysis revealed a relationship between the CFTR expression pattern and pN category, as well as a correlation between weak CFTR expression at the invasive front and shorter postoperative survival.