Early Predictors of 9-Year Disability in Pediatric Multiple Sclerosis

Objective The purpose of this study was to assess early predictors of 9-year disability in pediatric patients with multiple sclerosis. Methods Clinical and magnetic resonance imaging (MRI) assessments of 123 pediatric patients with multiple sclerosis were obtained at disease onset and after 1 and 2 years. A 9-year clinical follow-up was also performed. Cox proportional hazard and multivariable regression models were used to assess independent predictors of time to first relapse and 9-year outcomes. Results Time to first relapse was predicted by optic nerve lesions (hazard ratio [HR] = 2.10, p = 0.02) and high-efficacy treatment exposure (HR = 0.31, p = 0.005). Predictors of annualized relapse rate were: at baseline, presence of cerebellar (beta = -0.15, p < 0.001), cervical cord lesions (beta = 0.16, p = 0.003), and high-efficacy treatment exposure (beta = -0.14, p = 0.01); considering also 1-year variables, number of relapses (beta = 0.14, p = 0.002), and the previous baseline predictors; considering 2-year variables, time to first relapse (2-year: beta = -0.12, p = 0.01) entered, whereas high-efficacy treatment exposure exited the model. Predictors of 9-year disability worsening were: at baseline, presence of optic nerve lesions (odds ratio [OR] = 6.45, p = 0.01); considering 1-year and 2-year variables, Expanded Disability Status Scale (EDSS) changes (1-year: OR = 26.05, p < 0.001; 2-year: OR = 16.38, p = 0.02), and >= 2 new T2-lesions in 2 years (2-year: OR = 4.91, p = 0.02). Predictors of higher 9-year EDSS score were: at baseline, EDSS score (beta = 0.58, p < 0.001), presence of brainstem lesions (beta = 0.31, p = 0.04), and number of cervical cord lesions (beta = 0.22, p = 0.05); considering 1-year and 2-year variables, EDSS changes (1-year: beta = 0.79, p < 0.001; 2-year: beta = 0.55, p < 0.001), and >= 2 new T2-lesions (1-year: beta = 0.28, p = 0.03; 2-year: beta = 0.35, p = 0.01). Interpretation A complete baseline MRI assessment and an accurate clinical and MRI monitoring during the first 2 years of disease contribute to predict 9-year prognosis in pediatric patients with multiple sclerosis. ANN NEUROL 2021

Automated summary

This study assessed early predictors of 9-year disability in pediatric patients with multiple sclerosis. Factors such as optic nerve lesions and high-efficacy treatment exposure were found to predict time to first relapse. Changes in disease progression at different time points also influenced long-term disability outcomes.