Related references
Note: Only part of the references are listed.Prospective longitudinal atrophy in Alzheimer's disease correlates with the intensity and topography of baseline tau-PET
Renaud La Joie et al.
SCIENCE TRANSLATIONAL MEDICINE (2020)
APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid
Na Zhao et al.
SCIENCE TRANSLATIONAL MEDICINE (2020)
APOE genotype regulates pathology and disease progression in synucleinopathy
Albert A. Davis et al.
SCIENCE TRANSLATIONAL MEDICINE (2020)
APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline
Axel Montagne et al.
NATURE (2020)
Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration
Maud Gratuze et al.
JOURNAL OF CLINICAL INVESTIGATION (2020)
Antisense Oligonucleotide Therapies for Neurodegenerative Diseases
C. Frank Bennett et al.
Annual Review of Neuroscience (2019)
Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model
Yang Shi et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2019)
Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model
Tien-Phat V. Huynh et al.
MOLECULAR NEURODEGENERATION (2019)
Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer's disease
Oliver Preische et al.
NATURE MEDICINE (2019)
Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE
Samira Parhizkar et al.
NATURE NEUROSCIENCE (2019)
ApoE4 lowers age at onset in patients with frontotemporal dementia and tauopathy independent of amyloid-β copathology
Carolin Koriath et al.
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING (2019)
Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies
Borislav Dejanovic et al.
NEURON (2018)
Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight
Yang Shi et al.
NATURE REVIEWS IMMUNOLOGY (2018)
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
Susanne Krasemann et al.
IMMUNITY (2017)
ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy
Yang Shi et al.
NATURE (2017)
Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis
Tien-Phat V. Huynh et al.
NEURON (2017)
Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy
Sarah L. DeVos et al.
SCIENCE TRANSLATIONAL MEDICINE (2017)
A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease
Hadas Keren-Shaul et al.
CELL (2017)
Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers
Yuetiva Deming et al.
ACTA NEUROPATHOLOGICA (2017)
Gene-based association studies report genetic links for clinical subtypes of frontotemporal dementia
Aniket Mishra et al.
BRAIN (2017)
Genetic Restoration of Plasma ApoE Improves Cognition and Partially Restores Synaptic Defects in ApoE-Deficient Mice
Courtney Lane-Donovan et al.
JOURNAL OF NEUROSCIENCE (2016)
Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases
Mehtap Bacioglu et al.
NEURON (2016)
Complement and microglia mediate early synapse loss in Alzheimer mouse models
Soyon Hong et al.
SCIENCE (2016)
Association of Cerebrospinal Fluid Neurofilament Light Concentration With Alzheimer Disease Progression
Henrik Zetterberg et al.
JAMA NEUROLOGY (2016)
Apolipoprotein E4 Produced in GABAergic Interneurons Causes Learning and Memory Deficits in Mice
Johanna Knoferle et al.
JOURNAL OF NEUROSCIENCE (2014)
Effects of the Absence of Apolipoprotein E on Lipoproteins, Neurocognitive Function, and Retinal Function
Angel C. Y. Mak et al.
JAMA NEUROLOGY (2014)
Antisense Oligonucleotides: Treating Neurodegeneration at the Level of RNA
Sarah L. DeVos et al.
NEUROTHERAPEUTICS (2013)
Gene Transfer of Human Apoe Isoforms Results in Differential Modulation of Amyloid Deposition and Neurotoxicity in Mouse Brain
Eloise Hudry et al.
SCIENCE TRANSLATIONAL MEDICINE (2013)
APOE ε4 Increases Risk for Dementia in Pure Synucleinopathies
Debby Tsuang et al.
JAMA NEUROLOGY (2013)
Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature
Peter T. Nelson et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2012)
Sustained Therapeutic Reversal of Huntington's Disease by Transient Repression of Huntingtin Synthesis
Holly B. Kordasiewicz et al.
NEURON (2012)
Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
Dorothy P. Schafer et al.
NEURON (2012)
Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease
David M. Holtzman et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
Berislav V. Zlokovic
NATURE REVIEWS NEUROSCIENCE (2011)
P301S Mutant Human Tau Transgenic Mice Manifest Early Symptoms of Human Tauopathies with Dementia and Altered Sensorimotor Gating
Hiroki Takeuchi et al.
PLOS ONE (2011)
Human apoE Isoforms Differentially Regulate Brain Amyloid-β Peptide Clearance
Joseph M. Castellano et al.
SCIENCE TRANSLATIONAL MEDICINE (2011)
Neuropathological Alterations in Alzheimer Disease
Alberto Serrano-Pozo et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2011)
RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform
C. Frank Bennett et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY (2010)
ApoE4 Decreases Spine Density and Dendritic Complexity in Cortical Neurons In Vivo
Sonya B. Dumanis et al.
JOURNAL OF NEUROSCIENCE (2009)
Fibrillar amyloid-β burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease
Eric M. Reiman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Apolipoprotein E ε4 is associated with disease-specific effects on brain atrophy in Alzheimer's disease and frontotemporal dementia
Federica Agosta et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model
Yasumasa Yoshiyama et al.
NEURON (2007)
Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database
Lars Bertram et al.
NATURE GENETICS (2007)
Antisense oligonucleotide therapy for neurodegenerative disease
Richard A. Smith et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Dose dependent effect of APOE ε4 on behavioral symptoms in frontal lobe dementia
S Engelborghs et al.
NEUROBIOLOGY OF AGING (2006)
Gene delivery of human apolipoprotein E alters brain Aβ burden in a mouse model of Alzheimer's disease
JC Dodart et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Solid phase synthesis of phosphorothioate oligonucleotides utilizing diethyldithiocarbonate disulfide (DDD) as an efficient sulfur transfer reagent
ZS Cheruvallath et al.
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS (2003)